The Relevance of HTLV-1-associated Myelopathy/Tropical Spastic Paraparesis in Iran: A Review Study
Human T-cell lymphotropic virus type I (HTLV-I) is a retrovirus, which is the causative agent of adult T-cell leukaemia (ATL) and HTLV-I-associated myelopathy/tropical spastic paraparesis (HAM/TSP). Evidence suggests that the interaction of HTLV-1 with the cellular-immune system plays a key role in...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Mashhad University of Medical Sciences
2019-06-01
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| Series: | Reviews in Clinical Medicine |
| Subjects: | |
| Online Access: | http://rcm.mums.ac.ir/article_13417_96c33c8f510ff3106baab3ac45dfaaa2.pdf |
| Summary: | Human T-cell lymphotropic virus type I (HTLV-I) is a retrovirus, which is the causative agent of adult T-cell leukaemia (ATL) and HTLV-I-associated myelopathy/tropical spastic paraparesis (HAM/TSP). Evidence suggests that the interaction of HTLV-1 with the cellular-immune system plays a key role in the development of HAM/TSP. However, the main mechanism in this regard remains unknown. The present study aimed to review the HAM/TSP pathogenesis, current status of HTLV-1 in Iran, and available treatments for HTLV-1 infection. |
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| ISSN: | 2345-6256 2345-6892 |