Sensitivity of MRI tumor biomarkers to VEGFR inhibitor therapy in an orthotopic mouse glioma model.
MRI biomarkers of tumor edema, vascular permeability, blood volume, and average vessel caliber are increasingly being employed to assess the efficacy of tumor therapies. However, the dependence of these biomarkers on a number of physiological factors can compromise their sensitivity and complicate t...
Main Authors: | Christian T Farrar, Walid S Kamoun, Carsten D Ley, Young R Kim, Ciprian Catana, Seon J Kwon, Bruce R Rosen, Rakesh K Jain, A Gregory Sorensen |
---|---|
Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2011-03-01
|
Series: | PLoS ONE |
Online Access: | http://europepmc.org/articles/PMC3048404?pdf=render |
Similar Items
-
Perfluorocarbon emulsions radiosensitise brain tumors in carbogen breathing mice with orthotopic GL261 gliomas.
by: Lisa A Feldman, et al.
Published: (2017-01-01) -
Nilotinib Enhances Tumor Angiogenesis and Counteracts VEGFR2 Blockade in an Orthotopic Breast Cancer Xenograft Model with Desmoplastic Response
by: Sara Zafarnia, et al.
Published: (2017-11-01) -
Quantitative Evaluation of Intraventricular Delivery of Therapeutic Neural Stem Cells to Orthotopic Glioma
by: Margarita Gutova, et al.
Published: (2019-02-01) -
Retrovirus mediated suicide gene therapy and cytokine modulated immunotherapy for orthotopic glioma
by: Sheng-Che Lin, et al.
Published: (2011) -
MMP14 as a novel downstream target of VEGFR2 in migratory glioma-tropic neural stem cells
by: Nikita G. Alexiades, et al.
Published: (2015-11-01)