Disulfiram-induced reversible hypertension: A prospective case series and review of the literature
Disulfiram (DSF) is one of the recommended aids in the management of selected patients with alcohol dependence. Hypertension (HTN) as an adverse effect of DSF therapy is less understood. In our prospective case series of 7 subjects with co-morbid alcohol and nicotine dependence, a temporal, dose-dep...
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doaj-027268bd29dd45ab96922749ceecbdc22021-08-02T01:33:10ZengSAGE PublishingIndian Journal of Psychological Medicine0253-71762014-01-0136443443810.4103/0253-7176.140744Disulfiram-induced reversible hypertension: A prospective case series and review of the literatureRanganath R KulkarniSantosh I RamdurgBhavya K BairyDisulfiram (DSF) is one of the recommended aids in the management of selected patients with alcohol dependence. Hypertension (HTN) as an adverse effect of DSF therapy is less understood. In our prospective case series of 7 subjects with co-morbid alcohol and nicotine dependence, a temporal, dose-dependent, and reversible grade 1-3 HTN within 1-6 weeks of initiation of DSF therapy (125-500 mg/day) with no other detectable causes of HTN was noted. Challenges and strategies surrounding diagnosis and treatment along with mean change and percentage rise in blood pressure are described. Literature review and clinical description of case series may suggest neurobiological role in its causation. HTN may be a clinically significant, dose-dependent, and reversible adverse effect of DSF therapy, especially in co-morbid alcohol and nicotine-dependent patients. Awareness amongst clinicians may render better health care delivery to subjects with alcohol dependence.http://www.ijpm.info/article.asp?issn=0253-7176;year=2014;volume=36;issue=4;spage=434;epage=438;aulast=KulkarniAdverse effectalcoholismdisulfiramhypertension |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Ranganath R Kulkarni Santosh I Ramdurg Bhavya K Bairy |
spellingShingle |
Ranganath R Kulkarni Santosh I Ramdurg Bhavya K Bairy Disulfiram-induced reversible hypertension: A prospective case series and review of the literature Indian Journal of Psychological Medicine Adverse effect alcoholism disulfiram hypertension |
author_facet |
Ranganath R Kulkarni Santosh I Ramdurg Bhavya K Bairy |
author_sort |
Ranganath R Kulkarni |
title |
Disulfiram-induced reversible hypertension: A prospective case series and review of the literature |
title_short |
Disulfiram-induced reversible hypertension: A prospective case series and review of the literature |
title_full |
Disulfiram-induced reversible hypertension: A prospective case series and review of the literature |
title_fullStr |
Disulfiram-induced reversible hypertension: A prospective case series and review of the literature |
title_full_unstemmed |
Disulfiram-induced reversible hypertension: A prospective case series and review of the literature |
title_sort |
disulfiram-induced reversible hypertension: a prospective case series and review of the literature |
publisher |
SAGE Publishing |
series |
Indian Journal of Psychological Medicine |
issn |
0253-7176 |
publishDate |
2014-01-01 |
description |
Disulfiram (DSF) is one of the recommended aids in the management of selected patients with alcohol dependence. Hypertension (HTN) as an adverse effect of DSF therapy is less understood. In our prospective case series of 7 subjects with co-morbid alcohol and nicotine dependence, a temporal, dose-dependent, and reversible grade 1-3 HTN within 1-6 weeks of initiation of DSF therapy (125-500 mg/day) with no other detectable causes of HTN was noted. Challenges and strategies surrounding diagnosis and treatment along with mean change and percentage rise in blood pressure are described. Literature review and clinical description of case series may suggest neurobiological role in its causation. HTN may be a clinically significant, dose-dependent, and reversible adverse effect of DSF therapy, especially in co-morbid alcohol and nicotine-dependent patients. Awareness amongst clinicians may render better health care delivery to subjects with alcohol dependence. |
topic |
Adverse effect alcoholism disulfiram hypertension |
url |
http://www.ijpm.info/article.asp?issn=0253-7176;year=2014;volume=36;issue=4;spage=434;epage=438;aulast=Kulkarni |
work_keys_str_mv |
AT ranganathrkulkarni disulfiraminducedreversiblehypertensionaprospectivecaseseriesandreviewoftheliterature AT santoshiramdurg disulfiraminducedreversiblehypertensionaprospectivecaseseriesandreviewoftheliterature AT bhavyakbairy disulfiraminducedreversiblehypertensionaprospectivecaseseriesandreviewoftheliterature |
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