Pan-Cancer Mutational and Transcriptional Analysis of the Integrator Complex

Pan-Cancer Mutational and Transcriptional Analysis of the Integrator Complex

The integrator complex has been recently identified as a key regulator of RNA Polymerase II-mediated transcription, with many functions including the processing of small nuclear RNAs, the pause-release and elongation of polymerase during the transcription of protein coding genes, and the biogenesis...

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Bibliographic Details
Main Authors: Antonio Federico, Monica Rienzo, Ciro Abbondanza, Valerio Costa, Alfredo Ciccodicola, Amelia Casamassimi
Format: Article
Language:English
Published: MDPI AG 2017-04-01
Series:International Journal of Molecular Sciences
Subjects:
integrator complex
somatic mutations
transcriptome profiling
human cancers
TCGA data analysis
Online Access:http://www.mdpi.com/1422-0067/18/5/936

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