Hemorrhagic and thrombotic complications in patients with myeloproliferative diseases
OBJECTIVE: To correlate the incidence of hemorrhage and thrombosis to bleeding time (BT) and platelet aggregation in 27 consecutive patients with myeloproliferative diseases (MPD). DESIGN: Retrospective study. SETTING: Public tertiary referral center. PATIENTS: Eighteen patients with chronic myeloge...
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doaj-02794817e490471fbc809d3f2cab086e2020-11-24T20:59:19ZengAssociação Paulista de MedicinaSão Paulo Medical Journal1806-946011561575157910.1590/S1516-31801997000600004S1516-31801997000600004Hemorrhagic and thrombotic complications in patients with myeloproliferative diseasesCarla Valladares Vignal0Dayse Maria Lourenço1Maria Aparecida Eiko Noguti2Maria de Lourdes Ferrari Chauffaille3José Kerbauy4Universidade Federal de São PauloUniversidade Federal de São PauloUniversidade Federal de São PauloUniversidade Federal de São PauloUniversidade Federal de São PauloOBJECTIVE: To correlate the incidence of hemorrhage and thrombosis to bleeding time (BT) and platelet aggregation in 27 consecutive patients with myeloproliferative diseases (MPD). DESIGN: Retrospective study. SETTING: Public tertiary referral center. PATIENTS: Eighteen patients with chronic myelogenous leukemia (CML), 5 with polycytemia vera (PV), 2 with essential thrombocytemia (ET) and 2 with idiopathic myelofibrosis (MF). Duke's BT and epinephrine-induced platelet aggregation were performed on the patients and on 10 healthy individuals. RESULTS: Eleven patients presented symptoms (41 %): 9 with hemorrhage (33%) and 5 with thrombosis (19%).There were less symptomatic patients in the CML group (28%) than in the other MPD (67%), without statistical significance (Fisher, p=0.06). Duke's BT was longer in symptomatic patients (Mann-Whitney, p<0.05). Platelet aggregation was abnormal in 7 patients (26%) and 71% of them were symptomatic (Fisher, p = 0.07). CONCLUSIONS: The high incidence of bleeding and thrombosis in patients with MPD was related to prolonged BT, but not to platelet aggregation abnormalities.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-31801997000600004&lng=en&tlng=enMyeloproliferative DiseasesHemorrhageThrombosisBleeding timePlatelet aggregation |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Carla Valladares Vignal Dayse Maria Lourenço Maria Aparecida Eiko Noguti Maria de Lourdes Ferrari Chauffaille José Kerbauy |
spellingShingle |
Carla Valladares Vignal Dayse Maria Lourenço Maria Aparecida Eiko Noguti Maria de Lourdes Ferrari Chauffaille José Kerbauy Hemorrhagic and thrombotic complications in patients with myeloproliferative diseases São Paulo Medical Journal Myeloproliferative Diseases Hemorrhage Thrombosis Bleeding time Platelet aggregation |
author_facet |
Carla Valladares Vignal Dayse Maria Lourenço Maria Aparecida Eiko Noguti Maria de Lourdes Ferrari Chauffaille José Kerbauy |
author_sort |
Carla Valladares Vignal |
title |
Hemorrhagic and thrombotic complications in patients with myeloproliferative diseases |
title_short |
Hemorrhagic and thrombotic complications in patients with myeloproliferative diseases |
title_full |
Hemorrhagic and thrombotic complications in patients with myeloproliferative diseases |
title_fullStr |
Hemorrhagic and thrombotic complications in patients with myeloproliferative diseases |
title_full_unstemmed |
Hemorrhagic and thrombotic complications in patients with myeloproliferative diseases |
title_sort |
hemorrhagic and thrombotic complications in patients with myeloproliferative diseases |
publisher |
Associação Paulista de Medicina |
series |
São Paulo Medical Journal |
issn |
1806-9460 |
description |
OBJECTIVE: To correlate the incidence of hemorrhage and thrombosis to bleeding time (BT) and platelet aggregation in 27 consecutive patients with myeloproliferative diseases (MPD). DESIGN: Retrospective study. SETTING: Public tertiary referral center. PATIENTS: Eighteen patients with chronic myelogenous leukemia (CML), 5 with polycytemia vera (PV), 2 with essential thrombocytemia (ET) and 2 with idiopathic myelofibrosis (MF). Duke's BT and epinephrine-induced platelet aggregation were performed on the patients and on 10 healthy individuals. RESULTS: Eleven patients presented symptoms (41 %): 9 with hemorrhage (33%) and 5 with thrombosis (19%).There were less symptomatic patients in the CML group (28%) than in the other MPD (67%), without statistical significance (Fisher, p=0.06). Duke's BT was longer in symptomatic patients (Mann-Whitney, p<0.05). Platelet aggregation was abnormal in 7 patients (26%) and 71% of them were symptomatic (Fisher, p = 0.07). CONCLUSIONS: The high incidence of bleeding and thrombosis in patients with MPD was related to prolonged BT, but not to platelet aggregation abnormalities. |
topic |
Myeloproliferative Diseases Hemorrhage Thrombosis Bleeding time Platelet aggregation |
url |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-31801997000600004&lng=en&tlng=en |
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