Targeting γ-secretase triggers the selective enrichment of oligomeric APP-CTFs in brain extracellular vesicles from Alzheimer cell and mouse models

Targeting γ-secretase triggers the selective enrichment of oligomeric APP-CTFs in brain extracellular vesicles from Alzheimer cell and mouse models

Abstract Background We recently demonstrated an endolysosomal accumulation of the β-secretase-derived APP C-terminal fragment (CTF) C99 in brains of Alzheimer disease (AD) mouse models. Moreover, we showed that the treatment with the γ-secretase inhibitor (D6) led to further increased endolysosomal...

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Bibliographic Details
Main Authors: Inger Lauritzen, Anaïs Bécot, Alexandre Bourgeois, Raphaëlle Pardossi-Piquard, Maria-Grazia Biferi, Martine Barkats, Fréderic Checler
Format: Article
Language:English
Published: BMC 2019-12-01
Series:Translational Neurodegeneration
Subjects:
Extracellular vesicles
C99
APP-CTFs
Homo- and hetero-oligomerization
Endosomes
Lysosomes
Online Access:https://doi.org/10.1186/s40035-019-0176-6

Internet

https://doi.org/10.1186/s40035-019-0176-6

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