Genome-wide association study suggests that variation at the RCOR1 locus is associated with tinnitus in UK Biobank
Abstract Tinnitus is a prevalent condition in which perception of sound occurs without an external stimulus. It is often associated with pre-existing hearing loss or noise-induced damage to the auditory system. In some individuals it occurs frequently or even continuously and leads to considerable d...
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2021-03-01
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doaj-028cc4eb36d848ebb89c75495639e87a2021-03-21T12:34:00ZengNature Publishing GroupScientific Reports2045-23222021-03-0111111010.1038/s41598-021-85871-6Genome-wide association study suggests that variation at the RCOR1 locus is associated with tinnitus in UK BiobankHelena R. R. Wells0Fatin N. Zainul Abidin1Maxim B. Freidin2Frances M. K. Williams3Sally J. Dawson4Department of Twin Research and Genetic Epidemiology, School of Life Course Sciences, King’s College LondonUCL Ear Institute, University College LondonDepartment of Twin Research and Genetic Epidemiology, School of Life Course Sciences, King’s College LondonDepartment of Twin Research and Genetic Epidemiology, School of Life Course Sciences, King’s College LondonUCL Ear Institute, University College LondonAbstract Tinnitus is a prevalent condition in which perception of sound occurs without an external stimulus. It is often associated with pre-existing hearing loss or noise-induced damage to the auditory system. In some individuals it occurs frequently or even continuously and leads to considerable distress and difficulty sleeping. There is little knowledge of the molecular mechanisms involved in tinnitus which has hindered the development of treatments. Evidence suggests that tinnitus has a heritable component although previous genetic studies have not established specific risk factors. From a total of 172,608 UK Biobank participants who answered questions on tinnitus we performed a case–control genome-wide association study for self-reported tinnitus. Final sample size used in association analysis was N = 91,424. Three variants in close proximity to the RCOR1 gene reached genome wide significance: rs4906228 (p = 1.7E−08), rs4900545 (p = 1.8E−08) and 14:103042287_CT_C (p = 3.50E−08). RCOR1 encodes REST Corepressor 1, a component of a co-repressor complex involved in repressing neuronal gene expression in non-neuronal cells. Eleven other independent genetic loci reached a suggestive significance threshold of p < 1E−06.https://doi.org/10.1038/s41598-021-85871-6 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Helena R. R. Wells Fatin N. Zainul Abidin Maxim B. Freidin Frances M. K. Williams Sally J. Dawson |
spellingShingle |
Helena R. R. Wells Fatin N. Zainul Abidin Maxim B. Freidin Frances M. K. Williams Sally J. Dawson Genome-wide association study suggests that variation at the RCOR1 locus is associated with tinnitus in UK Biobank Scientific Reports |
author_facet |
Helena R. R. Wells Fatin N. Zainul Abidin Maxim B. Freidin Frances M. K. Williams Sally J. Dawson |
author_sort |
Helena R. R. Wells |
title |
Genome-wide association study suggests that variation at the RCOR1 locus is associated with tinnitus in UK Biobank |
title_short |
Genome-wide association study suggests that variation at the RCOR1 locus is associated with tinnitus in UK Biobank |
title_full |
Genome-wide association study suggests that variation at the RCOR1 locus is associated with tinnitus in UK Biobank |
title_fullStr |
Genome-wide association study suggests that variation at the RCOR1 locus is associated with tinnitus in UK Biobank |
title_full_unstemmed |
Genome-wide association study suggests that variation at the RCOR1 locus is associated with tinnitus in UK Biobank |
title_sort |
genome-wide association study suggests that variation at the rcor1 locus is associated with tinnitus in uk biobank |
publisher |
Nature Publishing Group |
series |
Scientific Reports |
issn |
2045-2322 |
publishDate |
2021-03-01 |
description |
Abstract Tinnitus is a prevalent condition in which perception of sound occurs without an external stimulus. It is often associated with pre-existing hearing loss or noise-induced damage to the auditory system. In some individuals it occurs frequently or even continuously and leads to considerable distress and difficulty sleeping. There is little knowledge of the molecular mechanisms involved in tinnitus which has hindered the development of treatments. Evidence suggests that tinnitus has a heritable component although previous genetic studies have not established specific risk factors. From a total of 172,608 UK Biobank participants who answered questions on tinnitus we performed a case–control genome-wide association study for self-reported tinnitus. Final sample size used in association analysis was N = 91,424. Three variants in close proximity to the RCOR1 gene reached genome wide significance: rs4906228 (p = 1.7E−08), rs4900545 (p = 1.8E−08) and 14:103042287_CT_C (p = 3.50E−08). RCOR1 encodes REST Corepressor 1, a component of a co-repressor complex involved in repressing neuronal gene expression in non-neuronal cells. Eleven other independent genetic loci reached a suggestive significance threshold of p < 1E−06. |
url |
https://doi.org/10.1038/s41598-021-85871-6 |
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