Th17 response and autophagy - main pathways implicated in the development of inflammatory bowel disease by genome-wide association studies: new factors involved in inflammatory bowel disease susceptibility
Inflammatory bowel disease (IBD) is an entity that mainly includes ulcerative colitis (UC) and Crohn's disease (CD). Improved health care, diet changes, and higher industrialization are associated with an increase in IBD prevalence. This supports the central role of environmental factors in the...
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doaj-028dc7d3064f4596979497e7b8d2c0962020-11-24T23:30:23ZengAran EdicionesRevista Espanola de Enfermedades Digestivas1130-01082015-09-011079560566S1130-01082015000900007Th17 response and autophagy - main pathways implicated in the development of inflammatory bowel disease by genome-wide association studies: new factors involved in inflammatory bowel disease susceptibilityRoberto Díaz-Peña0Eliana Valdés1Cecilia Cofré2Patricia Castro-Santos3Universidad Autónoma de ChileHospital de TalcaHospital de TalcaUniversidad Autónoma de ChileInflammatory bowel disease (IBD) is an entity that mainly includes ulcerative colitis (UC) and Crohn's disease (CD). Improved health care, diet changes, and higher industrialization are associated with an increase in IBD prevalence. This supports the central role of environmental factors in the pathology of this disease. However, IBD also shows a relevant genetic component as shown by high heritability. Classic genetic studies showed relevant associations between IBD susceptibility and genes involved in the immune response. This is consistent with prior theories about IBD development. According to these, contact of the immune system with a high number of harmless antigens from the diet and the bacterial flora should originate tolerance while preserving response against pathogens. Failure to achieve this balance may originate the typical inflammatory response associated with IBD. Recently, genome-wide association studies (GWASs) have confirmed the implication of the immune system, particularly the Th17 immune response, previously associated to other autoimmune diseases, and of autophagy. In this paper, the mechanisms involved in these two relevant pathways and their potential role in the pathogenesis of IBD are reviewed.http://scielo.isciii.es/scielo.php?script=sci_arttext&pid=S1130-01082015000900007&lng=en&tlng=enEnfermedad inflamatoria intestinalEnfermedad de CrohnColitis ulcerativaTh17AutofagiaEstudios de asociación de genoma completo |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Roberto Díaz-Peña Eliana Valdés Cecilia Cofré Patricia Castro-Santos |
spellingShingle |
Roberto Díaz-Peña Eliana Valdés Cecilia Cofré Patricia Castro-Santos Th17 response and autophagy - main pathways implicated in the development of inflammatory bowel disease by genome-wide association studies: new factors involved in inflammatory bowel disease susceptibility Revista Espanola de Enfermedades Digestivas Enfermedad inflamatoria intestinal Enfermedad de Crohn Colitis ulcerativa Th17 Autofagia Estudios de asociación de genoma completo |
author_facet |
Roberto Díaz-Peña Eliana Valdés Cecilia Cofré Patricia Castro-Santos |
author_sort |
Roberto Díaz-Peña |
title |
Th17 response and autophagy - main pathways implicated in the development of inflammatory bowel disease by genome-wide association studies: new factors involved in inflammatory bowel disease susceptibility |
title_short |
Th17 response and autophagy - main pathways implicated in the development of inflammatory bowel disease by genome-wide association studies: new factors involved in inflammatory bowel disease susceptibility |
title_full |
Th17 response and autophagy - main pathways implicated in the development of inflammatory bowel disease by genome-wide association studies: new factors involved in inflammatory bowel disease susceptibility |
title_fullStr |
Th17 response and autophagy - main pathways implicated in the development of inflammatory bowel disease by genome-wide association studies: new factors involved in inflammatory bowel disease susceptibility |
title_full_unstemmed |
Th17 response and autophagy - main pathways implicated in the development of inflammatory bowel disease by genome-wide association studies: new factors involved in inflammatory bowel disease susceptibility |
title_sort |
th17 response and autophagy - main pathways implicated in the development of inflammatory bowel disease by genome-wide association studies: new factors involved in inflammatory bowel disease susceptibility |
publisher |
Aran Ediciones |
series |
Revista Espanola de Enfermedades Digestivas |
issn |
1130-0108 |
publishDate |
2015-09-01 |
description |
Inflammatory bowel disease (IBD) is an entity that mainly includes ulcerative colitis (UC) and Crohn's disease (CD). Improved health care, diet changes, and higher industrialization are associated with an increase in IBD prevalence. This supports the central role of environmental factors in the pathology of this disease. However, IBD also shows a relevant genetic component as shown by high heritability. Classic genetic studies showed relevant associations between IBD susceptibility and genes involved in the immune response. This is consistent with prior theories about IBD development. According to these, contact of the immune system with a high number of harmless antigens from the diet and the bacterial flora should originate tolerance while preserving response against pathogens. Failure to achieve this balance may originate the typical inflammatory response associated with IBD. Recently, genome-wide association studies (GWASs) have confirmed the implication of the immune system, particularly the Th17 immune response, previously associated to other autoimmune diseases, and of autophagy. In this paper, the mechanisms involved in these two relevant pathways and their potential role in the pathogenesis of IBD are reviewed. |
topic |
Enfermedad inflamatoria intestinal Enfermedad de Crohn Colitis ulcerativa Th17 Autofagia Estudios de asociación de genoma completo |
url |
http://scielo.isciii.es/scielo.php?script=sci_arttext&pid=S1130-01082015000900007&lng=en&tlng=en |
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