Mucosal IL-4R antagonist HIV vaccination with SOSIP-gp140 booster can induce high-quality cytotoxic CD4+/CD8+ T cells and humoral responses in macaques

Mucosal IL-4R antagonist HIV vaccination with SOSIP-gp140 booster can induce high-quality cytotoxic CD4+/CD8+ T cells and humoral responses in macaques

Abstract Inducing humoral, cellular and mucosal immunity is likely to improve the effectiveness of HIV-1 vaccine strategies. Here, we tested a vaccine regimen in pigtail macaques using an intranasal (i.n.) recombinant Fowl Pox Virus (FPV)-gag pol env-IL-4R antagonist prime, intramuscular (i.m.) reco...

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Bibliographic Details
Main Authors:	Z. Li, M. Khanna, S. L. Grimley, P. Ellenberg, C. A. Gonelli, Wen Shi Lee, T. H. Amarasena, A. D. Kelleher, D. F. J. Purcell, S. J. Kent, C. Ranasinghe
Format:	Article
Language:	English
Published:	Nature Publishing Group 2020-12-01
Series:	Scientific Reports
Online Access:	https://doi.org/10.1038/s41598-020-79172-7

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