National burden of cancer in Italy, 1990–2017: a systematic analysis for the global burden of disease study 2017

Abstract We monitored the burden of cancer in Italy and its trends over the last three decades, providing estimates of cancer incidence, mortality, years of life lost, years lived with disability, and disability-adjusted life-years (DALYs), for cancer overall and 30 cancer sites using data from the...

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Main Authors: Cristina Bosetti, Eugenio Traini, Tahiya Alam, Christine A. Allen, Giulia Carreras, Kelly Compton, Christina Fitzmaurice, Lisa M. Force, Silvano Gallus, Giuseppe Gorini, James D. Harvey, Jonathan M. Kocarnik, Carlo La Vecchia, Alessandra Lugo, Mohsen Naghavi, Alyssa Pennini, Cristiano Piccinelli, Luca Ronfani, Rixing Xu, Lorenzo Monasta
Format: Article
Language:English
Published: Nature Publishing Group 2020-12-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-020-79176-3
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spelling doaj-0298451ee38c4036acb592667df790682020-12-20T12:31:50ZengNature Publishing GroupScientific Reports2045-23222020-12-0110111010.1038/s41598-020-79176-3National burden of cancer in Italy, 1990–2017: a systematic analysis for the global burden of disease study 2017Cristina Bosetti0Eugenio Traini1Tahiya Alam2Christine A. Allen3Giulia Carreras4Kelly Compton5Christina Fitzmaurice6Lisa M. Force7Silvano Gallus8Giuseppe Gorini9James D. Harvey10Jonathan M. Kocarnik11Carlo La Vecchia12Alessandra Lugo13Mohsen Naghavi14Alyssa Pennini15Cristiano Piccinelli16Luca Ronfani17Rixing Xu18Lorenzo Monasta19Department of Oncology, Istituto di Ricerche Farmacologiche Mario Negri IRCCSClinical Epidemiology and Public Health Research Unit, Institute for Maternal and Child Health IRCCS Burlo GarofoloInstitute for Health Metrics and Evaluation, University of WashingtonInstitute for Health Metrics and Evaluation, University of WashingtonOncologic Network, Prevention, and Research InstituteInstitute for Health Metrics and Evaluation, University of WashingtonInstitute for Health Metrics and Evaluation, University of WashingtonDepartment of Oncology, St. Jude Children’s Research HospitalDepartment of Environmental Health Sciences, Istituto Di Ricerche Farmacologiche Mario Negri IRCCSOncologic Network, Prevention, and Research InstituteInstitute for Health Metrics and Evaluation, University of WashingtonInstitute for Health Metrics and Evaluation, University of WashingtonDepartment of Clinical Sciences and Community Health, University of MilanDepartment of Environmental Health Sciences, Istituto Di Ricerche Farmacologiche Mario Negri IRCCSInstitute for Health Metrics and Evaluation, University of WashingtonInstitute for Health Metrics and Evaluation, University of WashingtonCPO Piemonte, AOU Città Della Salute E Della ScienzaClinical Epidemiology and Public Health Research Unit, Institute for Maternal and Child Health IRCCS Burlo GarofoloInstitute for Health Metrics and Evaluation, University of WashingtonClinical Epidemiology and Public Health Research Unit, Institute for Maternal and Child Health IRCCS Burlo GarofoloAbstract We monitored the burden of cancer in Italy and its trends over the last three decades, providing estimates of cancer incidence, mortality, years of life lost, years lived with disability, and disability-adjusted life-years (DALYs), for cancer overall and 30 cancer sites using data from the Global Burden of Disease study 2017. An overview of mortality trends between 1990 and 2017 was also provided. In 2017, there were 254,336 new cancer cases in men and 214,994 in women, corresponding to an age-standardized incidence rate (ASIR) of 438 and 330/100,000, respectively. Between 1990 and 2017, incident cancer cases, and, to a lesser extent, ASIRs significantly increased overall and for almost all cancer sites, but ASIRs significantly declined for lung and other tobacco-related neoplasms. In 2017, there were 101,659 cancer deaths in men (age-standardized death rate, ASDR, 158.5/100,000) and 78,918 in women (ASDR 93.9/100,000). Cancer deaths significantly increased between 1990 and 2017 (+ 18%), but ASDR significantly decreased (− 28%). Deaths significantly increased for many cancer sites, but decreased for stomach, esophageal, laryngeal, Hodgkin lymphoma, and testicular cancer. ASDRs significantly decreased for most neoplasms, with the main exceptions of cancer of the pancreas and uterus, and multiple myeloma. In 2017, cancer caused 3,204,000 DALYs. Between 1990 and 2017, DALYs and age-standardized DALY rates significantly declined (-3.4% and -33%, respectively). Age-standardized mortality rates in Italy showed favorable patterns over the last few decades. However, the absolute number of cancer cases and, to a lower extent, of cancer deaths increased likely due to the progressive ageing of the population, this calling for a continuous effort in cancer prevention, early diagnosis, and treatment.https://doi.org/10.1038/s41598-020-79176-3
collection DOAJ
language English
format Article
sources DOAJ
author Cristina Bosetti
Eugenio Traini
Tahiya Alam
Christine A. Allen
Giulia Carreras
Kelly Compton
Christina Fitzmaurice
Lisa M. Force
Silvano Gallus
Giuseppe Gorini
James D. Harvey
Jonathan M. Kocarnik
Carlo La Vecchia
Alessandra Lugo
Mohsen Naghavi
Alyssa Pennini
Cristiano Piccinelli
Luca Ronfani
Rixing Xu
Lorenzo Monasta
spellingShingle Cristina Bosetti
Eugenio Traini
Tahiya Alam
Christine A. Allen
Giulia Carreras
Kelly Compton
Christina Fitzmaurice
Lisa M. Force
Silvano Gallus
Giuseppe Gorini
James D. Harvey
Jonathan M. Kocarnik
Carlo La Vecchia
Alessandra Lugo
Mohsen Naghavi
Alyssa Pennini
Cristiano Piccinelli
Luca Ronfani
Rixing Xu
Lorenzo Monasta
National burden of cancer in Italy, 1990–2017: a systematic analysis for the global burden of disease study 2017
Scientific Reports
author_facet Cristina Bosetti
Eugenio Traini
Tahiya Alam
Christine A. Allen
Giulia Carreras
Kelly Compton
Christina Fitzmaurice
Lisa M. Force
Silvano Gallus
Giuseppe Gorini
James D. Harvey
Jonathan M. Kocarnik
Carlo La Vecchia
Alessandra Lugo
Mohsen Naghavi
Alyssa Pennini
Cristiano Piccinelli
Luca Ronfani
Rixing Xu
Lorenzo Monasta
author_sort Cristina Bosetti
title National burden of cancer in Italy, 1990–2017: a systematic analysis for the global burden of disease study 2017
title_short National burden of cancer in Italy, 1990–2017: a systematic analysis for the global burden of disease study 2017
title_full National burden of cancer in Italy, 1990–2017: a systematic analysis for the global burden of disease study 2017
title_fullStr National burden of cancer in Italy, 1990–2017: a systematic analysis for the global burden of disease study 2017
title_full_unstemmed National burden of cancer in Italy, 1990–2017: a systematic analysis for the global burden of disease study 2017
title_sort national burden of cancer in italy, 1990–2017: a systematic analysis for the global burden of disease study 2017
publisher Nature Publishing Group
series Scientific Reports
issn 2045-2322
publishDate 2020-12-01
description Abstract We monitored the burden of cancer in Italy and its trends over the last three decades, providing estimates of cancer incidence, mortality, years of life lost, years lived with disability, and disability-adjusted life-years (DALYs), for cancer overall and 30 cancer sites using data from the Global Burden of Disease study 2017. An overview of mortality trends between 1990 and 2017 was also provided. In 2017, there were 254,336 new cancer cases in men and 214,994 in women, corresponding to an age-standardized incidence rate (ASIR) of 438 and 330/100,000, respectively. Between 1990 and 2017, incident cancer cases, and, to a lesser extent, ASIRs significantly increased overall and for almost all cancer sites, but ASIRs significantly declined for lung and other tobacco-related neoplasms. In 2017, there were 101,659 cancer deaths in men (age-standardized death rate, ASDR, 158.5/100,000) and 78,918 in women (ASDR 93.9/100,000). Cancer deaths significantly increased between 1990 and 2017 (+ 18%), but ASDR significantly decreased (− 28%). Deaths significantly increased for many cancer sites, but decreased for stomach, esophageal, laryngeal, Hodgkin lymphoma, and testicular cancer. ASDRs significantly decreased for most neoplasms, with the main exceptions of cancer of the pancreas and uterus, and multiple myeloma. In 2017, cancer caused 3,204,000 DALYs. Between 1990 and 2017, DALYs and age-standardized DALY rates significantly declined (-3.4% and -33%, respectively). Age-standardized mortality rates in Italy showed favorable patterns over the last few decades. However, the absolute number of cancer cases and, to a lower extent, of cancer deaths increased likely due to the progressive ageing of the population, this calling for a continuous effort in cancer prevention, early diagnosis, and treatment.
url https://doi.org/10.1038/s41598-020-79176-3
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