Patterns of Sociodemographic and Clinicopathologic Characteristics of Stages II and III Colorectal Cancer Patients by Age: Examining Potential Mechanisms of Young-Onset Disease
Background and Aims. As a first step toward understanding the increasing incidence of colorectal cancer (CRC) in younger (age < 50) populations, we examined demographic, clinicopathologic, and socioeconomic characteristics and treatment receipt in a population-based sample of patients newly diagn...
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Series: | Journal of Cancer Epidemiology |
Online Access: | http://dx.doi.org/10.1155/2017/4024580 |
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doaj-02a053206f1d414aa43b7c90b987af352020-11-25T00:02:18ZengHindawi LimitedJournal of Cancer Epidemiology1687-85581687-85662017-01-01201710.1155/2017/40245804024580Patterns of Sociodemographic and Clinicopathologic Characteristics of Stages II and III Colorectal Cancer Patients by Age: Examining Potential Mechanisms of Young-Onset DiseaseCaitlin C. Murphy0Hanna K. Sanoff1Karyn B. Stitzenberg2John A. Baron3Jennifer L. Lund4Robert S. Sandler5Division of Epidemiology, Department of Clinical Sciences, University of Texas Southwestern Medical Center, Dallas, TX, USALineberger Comprehensive Cancer Center, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USALineberger Comprehensive Cancer Center, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USADepartment of Epidemiology, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USADepartment of Epidemiology, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USADepartment of Epidemiology, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USABackground and Aims. As a first step toward understanding the increasing incidence of colorectal cancer (CRC) in younger (age < 50) populations, we examined demographic, clinicopathologic, and socioeconomic characteristics and treatment receipt in a population-based sample of patients newly diagnosed with stages II and III CRC. Methods. Patients were sampled from the National Cancer Institute’s Patterns of Care studies in 1990/91, 1995, 2000, 2005, and 2010 (n=6,862). Tumor characteristics and treatment data were obtained through medical record review and physician verification. We compared sociodemographic and clinicopathologic characteristics and treatment patterns of younger (age < 50) and older (age 50–69, age ≥ 70) CRC patients. Results. Younger patients were more likely to be black (13%) and Hispanic (15%) than patients aged 50–69 years (11% and 10%, resp.) and ≥70 years (7% each). A larger proportion of young white (41%) and Hispanic (33%) patients had rectal tumors, whereas tumors in the right colon were the most common in young black patients (39%). The majority of younger patients received chemotherapy and radiation therapy, although receipt of microsatellite instability testing was suboptimal (27%). Conclusion. Characteristics of patients diagnosed with young-onset CRC differ considerably by race/ethnicity, with a higher proportion of black and Hispanic patients diagnosed at the age of < 50 years.http://dx.doi.org/10.1155/2017/4024580 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Caitlin C. Murphy Hanna K. Sanoff Karyn B. Stitzenberg John A. Baron Jennifer L. Lund Robert S. Sandler |
spellingShingle |
Caitlin C. Murphy Hanna K. Sanoff Karyn B. Stitzenberg John A. Baron Jennifer L. Lund Robert S. Sandler Patterns of Sociodemographic and Clinicopathologic Characteristics of Stages II and III Colorectal Cancer Patients by Age: Examining Potential Mechanisms of Young-Onset Disease Journal of Cancer Epidemiology |
author_facet |
Caitlin C. Murphy Hanna K. Sanoff Karyn B. Stitzenberg John A. Baron Jennifer L. Lund Robert S. Sandler |
author_sort |
Caitlin C. Murphy |
title |
Patterns of Sociodemographic and Clinicopathologic Characteristics of Stages II and III Colorectal Cancer Patients by Age: Examining Potential Mechanisms of Young-Onset Disease |
title_short |
Patterns of Sociodemographic and Clinicopathologic Characteristics of Stages II and III Colorectal Cancer Patients by Age: Examining Potential Mechanisms of Young-Onset Disease |
title_full |
Patterns of Sociodemographic and Clinicopathologic Characteristics of Stages II and III Colorectal Cancer Patients by Age: Examining Potential Mechanisms of Young-Onset Disease |
title_fullStr |
Patterns of Sociodemographic and Clinicopathologic Characteristics of Stages II and III Colorectal Cancer Patients by Age: Examining Potential Mechanisms of Young-Onset Disease |
title_full_unstemmed |
Patterns of Sociodemographic and Clinicopathologic Characteristics of Stages II and III Colorectal Cancer Patients by Age: Examining Potential Mechanisms of Young-Onset Disease |
title_sort |
patterns of sociodemographic and clinicopathologic characteristics of stages ii and iii colorectal cancer patients by age: examining potential mechanisms of young-onset disease |
publisher |
Hindawi Limited |
series |
Journal of Cancer Epidemiology |
issn |
1687-8558 1687-8566 |
publishDate |
2017-01-01 |
description |
Background and Aims. As a first step toward understanding the increasing incidence of colorectal cancer (CRC) in younger (age < 50) populations, we examined demographic, clinicopathologic, and socioeconomic characteristics and treatment receipt in a population-based sample of patients newly diagnosed with stages II and III CRC. Methods. Patients were sampled from the National Cancer Institute’s Patterns of Care studies in 1990/91, 1995, 2000, 2005, and 2010 (n=6,862). Tumor characteristics and treatment data were obtained through medical record review and physician verification. We compared sociodemographic and clinicopathologic characteristics and treatment patterns of younger (age < 50) and older (age 50–69, age ≥ 70) CRC patients. Results. Younger patients were more likely to be black (13%) and Hispanic (15%) than patients aged 50–69 years (11% and 10%, resp.) and ≥70 years (7% each). A larger proportion of young white (41%) and Hispanic (33%) patients had rectal tumors, whereas tumors in the right colon were the most common in young black patients (39%). The majority of younger patients received chemotherapy and radiation therapy, although receipt of microsatellite instability testing was suboptimal (27%). Conclusion. Characteristics of patients diagnosed with young-onset CRC differ considerably by race/ethnicity, with a higher proportion of black and Hispanic patients diagnosed at the age of < 50 years. |
url |
http://dx.doi.org/10.1155/2017/4024580 |
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