The temporal expression pattern of alpha-synuclein modulates olfactory neurogenesis in transgenic mice.
Adult neurogenesis mirrors the brain´s endogenous capacity to generate new neurons throughout life. In the subventricular zone/ olfactory bulb system adult neurogenesis is linked to physiological olfactory function and has been shown to be impaired in murine models of neuronal alpha-Synuclein overex...
Main Authors: | Sebastian R Schreglmann, Martin Regensburger, Edward Rockenstein, Eliezer Masliah, Wei Xiang, Jürgen Winkler, Beate Winner |
---|---|
Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2015-01-01
|
Series: | PLoS ONE |
Online Access: | http://europepmc.org/articles/PMC4427489?pdf=render |
Similar Items
-
Glial A30P alpha-synuclein pathology segregates neurogenesis from anxiety-related behavior in conditional transgenic mice
by: Franz Marxreiter, et al.
Published: (2013-11-01) -
Intracellular A53T Mutant α-Synuclein Impairs Adult Hippocampal Newborn Neuron Integration
by: Martin Regensburger, et al.
Published: (2020-11-01) -
Impaired adult olfactory bulb neurogenesis in the R6/2 mouse model of Huntington's disease
by: Kohl Zacharias, et al.
Published: (2010-09-01) -
Role of Alterations in Protein Kinase p38γ in the Pathogenesis of the Synaptic Pathology in Dementia With Lewy Bodies and α-Synuclein Transgenic Models
by: Michiyo Iba, et al.
Published: (2020-03-01) -
Severely impaired hippocampal neurogenesis associates with an early serotonergic deficit in a BAC α-synuclein transgenic rat model of Parkinson's disease
by: Zacharias Kohl, et al.
Published: (2016-01-01)