The combination of dibenzazepine and a DOT1L inhibitor enables a stable maintenance of human naïve-state pluripotency in non-hypoxic conditions

The combination of dibenzazepine and a DOT1L inhibitor enables a stable maintenance of human naïve-state pluripotency in non-hypoxic conditions

Conventional human pluripotent stem cells (hPSCs), known for being in a primed state, are pivotal for both basic research and clinical applications since such cells produce various types of differentiated cells. Recent reports on PSCs shed light on the pluripotent hierarchy of stem cells and have pr...

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Bibliographic Details
Main Authors: Wataru Isono, Tomoyuki Kawasaki, Justin K. Ichida, Takuya Ayabe, Osamu Hiraike, Akihiro Umezawa, Hidenori Akutsu
Format: Article
Language:English
Published: Elsevier 2020-12-01
Series:Regenerative Therapy
Subjects:
Naïve
Non-hypoxia
LIF
Pluripotent stem cell
Primed
Online Access:http://www.sciencedirect.com/science/article/pii/S2352320420300663

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