Migration of the 3T3 Cell with a Lamellipodium on Various Stiffness Substrates—Tensegrity Model

Migration of the 3T3 Cell with a Lamellipodium on Various Stiffness Substrates—Tensegrity Model

Changes in mechanical stimuli and the physiological environment are sensed by the cell. Thesechanges influence the cell’s motility patterns. The cell’s directional migration is dependent on the substrate stiffness. To describe such behavior of a cell, a tensegrity model was used. Cells with an exten...

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Bibliographic Details
Main Author: Arkady Voloshin
Format: Article
Language:English
Published: MDPI AG 2020-09-01
Series:Applied Sciences
Subjects:
strain energy
tensegrity
finite element analysis
cell migration
substrate stiffness
Online Access:https://www.mdpi.com/2076-3417/10/19/6644
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spelling doaj-02aab79c9cc74048811d8bac3070644e2020-11-25T03:47:59ZengMDPI AGApplied Sciences2076-34172020-09-01106644664410.3390/app10196644Migration of the 3T3 Cell with a Lamellipodium on Various Stiffness Substrates—Tensegrity ModelArkady Voloshin0Department of Mechanical Engineering and Mechanics and Department of Bioengineering, Lehigh University, Bethlehem, PA 18017, USAChanges in mechanical stimuli and the physiological environment are sensed by the cell. Thesechanges influence the cell’s motility patterns. The cell’s directional migration is dependent on the substrate stiffness. To describe such behavior of a cell, a tensegrity model was used. Cells with an extended lamellipodium were modeled. The internal elastic strain energy of a cell attached to the substrates with different stiffnesses was evaluated. The obtained results show that on the stiffer substrate, the elastic strain energy of the cell adherent to this substrate decreases. Therefore, the substrate stiffness is one of the parameters that govern the cell’s directional movement.https://www.mdpi.com/2076-3417/10/19/6644strain energytensegrityfinite element analysiscell migrationsubstrate stiffness
collection DOAJ
language English
format Article
sources DOAJ
author Arkady Voloshin
spellingShingle Arkady Voloshin
Migration of the 3T3 Cell with a Lamellipodium on Various Stiffness Substrates—Tensegrity Model
Applied Sciences
strain energy
tensegrity
finite element analysis
cell migration
substrate stiffness
author_facet Arkady Voloshin
author_sort Arkady Voloshin
title Migration of the 3T3 Cell with a Lamellipodium on Various Stiffness Substrates—Tensegrity Model
title_short Migration of the 3T3 Cell with a Lamellipodium on Various Stiffness Substrates—Tensegrity Model
title_full Migration of the 3T3 Cell with a Lamellipodium on Various Stiffness Substrates—Tensegrity Model
title_fullStr Migration of the 3T3 Cell with a Lamellipodium on Various Stiffness Substrates—Tensegrity Model
title_full_unstemmed Migration of the 3T3 Cell with a Lamellipodium on Various Stiffness Substrates—Tensegrity Model
title_sort migration of the 3t3 cell with a lamellipodium on various stiffness substrates—tensegrity model
publisher MDPI AG
series Applied Sciences
issn 2076-3417
publishDate 2020-09-01
description Changes in mechanical stimuli and the physiological environment are sensed by the cell. Thesechanges influence the cell’s motility patterns. The cell’s directional migration is dependent on the substrate stiffness. To describe such behavior of a cell, a tensegrity model was used. Cells with an extended lamellipodium were modeled. The internal elastic strain energy of a cell attached to the substrates with different stiffnesses was evaluated. The obtained results show that on the stiffer substrate, the elastic strain energy of the cell adherent to this substrate decreases. Therefore, the substrate stiffness is one of the parameters that govern the cell’s directional movement.
topic strain energy
tensegrity
finite element analysis
cell migration
substrate stiffness
url https://www.mdpi.com/2076-3417/10/19/6644
work_keys_str_mv AT arkadyvoloshin migrationofthe3t3cellwithalamellipodiumonvariousstiffnesssubstratestensegritymodel
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