Plasminogen deficiency causes reduced corticospinal axonal plasticity and functional recovery after stroke in mice.

Plasminogen deficiency causes reduced corticospinal axonal plasticity and functional recovery after stroke in mice.

Tissue plasminogen activator (tPA) has been implicated in neurite outgrowth and neurological recovery post stroke. tPA converts the zymogen plasminogen (Plg) into plasmin. In this study, using plasminogen knockout (Plg-/-) mice and their Plg-native littermates (Plg+/+), we investigated the role of P...

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Bibliographic Details
Main Authors: Zhongwu Liu, Yi Li, Jianyong Qian, Yisheng Cui, Michael Chopp
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3986098?pdf=render

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