Blocking α2δ-1 Subunit Reduces Bladder Hypersensitivity and Inflammation in a Cystitis Mouse Model by Decreasing NF-kB Pathway Activation

Blocking α2δ-1 Subunit Reduces Bladder Hypersensitivity and Inflammation in a Cystitis Mouse Model by Decreasing NF-kB Pathway Activation

Bladder pain is frequently associated with bladder inflammation, as in conditions like interstitial cystitis (IC), for which current analgesic therapies have limited efficacy. The antinociceptive effect of alpha-2-delta (α2δ) ligands on inflammation-associated visceral pain like that experienced in...

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Bibliographic Details
Main Authors: Ludivine Boudieu, Sarah Mountadem, Amandine Lashermes, Mathieu Meleine, Lauriane Ulmann, François Rassendren, Youssef Aissouni, Benoit Sion, Frédéric Antonio Carvalho, Denis Ardid
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-02-01
Series:Frontiers in Pharmacology
Subjects:
cystitis mouse model
α2δ-1 ligands treatment
pain
inflammation
NF-kB pathway
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2019.00133/full

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