Ellagitannins in Cancer Chemoprevention and Therapy
It is universally accepted that diets rich in fruit and vegetables lead to reduction in the risk of common forms of cancer and are useful in cancer prevention. Indeed edible vegetables and fruits contain a wide variety of phytochemicals with proven antioxidant, anti-carcinogenic, and chemopreventive...
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doaj-02b43f17468347178c9dd2734bffe1972020-11-24T22:13:52ZengMDPI AGToxins2072-66512016-05-018515110.3390/toxins8050151toxins8050151Ellagitannins in Cancer Chemoprevention and TherapyTariq Ismail0Cinzia Calcabrini1Anna Rita Diaz2Carmela Fimognari3Eleonora Turrini4Elena Catanzaro5Saeed Akhtar6Piero Sestili7Institute of Food Science & Nutrition, Faculty of Agricultural Sciences and Technology, Bahauddin Zakariya University, Bosan Road, Multan 60800, Punjab, PakistanDepartment of Biomolecular Sciences, University of Urbino Carlo Bo, Via I Maggetti 26, 61029 Urbino (PU), ItalyDepartment of Biomolecular Sciences, University of Urbino Carlo Bo, Via I Maggetti 26, 61029 Urbino (PU), ItalyDepartment for Life Quality Studies, Alma Mater Studiorum-University of Bologna, Corso d'Augusto 237, 47921 Rimini (RN), ItalyDepartment for Life Quality Studies, Alma Mater Studiorum-University of Bologna, Corso d'Augusto 237, 47921 Rimini (RN), ItalyDepartment for Life Quality Studies, Alma Mater Studiorum-University of Bologna, Corso d'Augusto 237, 47921 Rimini (RN), ItalyInstitute of Food Science & Nutrition, Faculty of Agricultural Sciences and Technology, Bahauddin Zakariya University, Bosan Road, Multan 60800, Punjab, PakistanDepartment of Biomolecular Sciences, University of Urbino Carlo Bo, Via I Maggetti 26, 61029 Urbino (PU), ItalyIt is universally accepted that diets rich in fruit and vegetables lead to reduction in the risk of common forms of cancer and are useful in cancer prevention. Indeed edible vegetables and fruits contain a wide variety of phytochemicals with proven antioxidant, anti-carcinogenic, and chemopreventive activity; moreover, some of these phytochemicals also display direct antiproliferative activity towards tumor cells, with the additional advantage of high tolerability and low toxicity. The most important dietary phytochemicals are isothiocyanates, ellagitannins (ET), polyphenols, indoles, flavonoids, retinoids, tocopherols. Among this very wide panel of compounds, ET represent an important class of phytochemicals which are being increasingly investigated for their chemopreventive and anticancer activities. This article reviews the chemistry, the dietary sources, the pharmacokinetics, the evidence on chemopreventive efficacy and the anticancer activity of ET with regard to the most sensitive tumors, as well as the mechanisms underlying their clinically-valuable properties.http://www.mdpi.com/2072-6651/8/5/151ellagitanninsphytochemicalscancerchemopreventioncancer therapysafety |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Tariq Ismail Cinzia Calcabrini Anna Rita Diaz Carmela Fimognari Eleonora Turrini Elena Catanzaro Saeed Akhtar Piero Sestili |
spellingShingle |
Tariq Ismail Cinzia Calcabrini Anna Rita Diaz Carmela Fimognari Eleonora Turrini Elena Catanzaro Saeed Akhtar Piero Sestili Ellagitannins in Cancer Chemoprevention and Therapy Toxins ellagitannins phytochemicals cancer chemoprevention cancer therapy safety |
author_facet |
Tariq Ismail Cinzia Calcabrini Anna Rita Diaz Carmela Fimognari Eleonora Turrini Elena Catanzaro Saeed Akhtar Piero Sestili |
author_sort |
Tariq Ismail |
title |
Ellagitannins in Cancer Chemoprevention and Therapy |
title_short |
Ellagitannins in Cancer Chemoprevention and Therapy |
title_full |
Ellagitannins in Cancer Chemoprevention and Therapy |
title_fullStr |
Ellagitannins in Cancer Chemoprevention and Therapy |
title_full_unstemmed |
Ellagitannins in Cancer Chemoprevention and Therapy |
title_sort |
ellagitannins in cancer chemoprevention and therapy |
publisher |
MDPI AG |
series |
Toxins |
issn |
2072-6651 |
publishDate |
2016-05-01 |
description |
It is universally accepted that diets rich in fruit and vegetables lead to reduction in the risk of common forms of cancer and are useful in cancer prevention. Indeed edible vegetables and fruits contain a wide variety of phytochemicals with proven antioxidant, anti-carcinogenic, and chemopreventive activity; moreover, some of these phytochemicals also display direct antiproliferative activity towards tumor cells, with the additional advantage of high tolerability and low toxicity. The most important dietary phytochemicals are isothiocyanates, ellagitannins (ET), polyphenols, indoles, flavonoids, retinoids, tocopherols. Among this very wide panel of compounds, ET represent an important class of phytochemicals which are being increasingly investigated for their chemopreventive and anticancer activities. This article reviews the chemistry, the dietary sources, the pharmacokinetics, the evidence on chemopreventive efficacy and the anticancer activity of ET with regard to the most sensitive tumors, as well as the mechanisms underlying their clinically-valuable properties. |
topic |
ellagitannins phytochemicals cancer chemoprevention cancer therapy safety |
url |
http://www.mdpi.com/2072-6651/8/5/151 |
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