Squamous cell transformation as a mechanism of acquired resistance to tyrosine kinase inhibitor in EGFR‐mutated lung adenocarcinoma: a report of two cases
Pathological transformation to squamous cell carcinoma after epidermal growth factor receptor (EGFR)‐tyrosine kinase inhibitor treatment has been reported, but details of the transformation remain unclear. We report two cases with transformation to squamous cell carcinoma. The first case was a 61‐ye...
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doaj-02baf5593ad44324a81a245c43cc80a42020-11-25T02:11:15ZengWileyRespirology Case Reports2051-33802020-03-0182n/an/a10.1002/rcr2.521Squamous cell transformation as a mechanism of acquired resistance to tyrosine kinase inhibitor in EGFR‐mutated lung adenocarcinoma: a report of two casesHironori Uruga0Takeshi Fujii1Nobuyuki Nakamura2Shuhei Moriguchi3Kazuma Kishi4Hisashi Takaya5Department of Respiratory Medicine, Respiratory Center Toranomon Hospital Tokyo JapanOkinaka Memorial Institute for Medical Research Tokyo JapanDepartment of Pathology and Clinical Laboratories National Cancer Center Hospital East Kashiwa JapanDepartment of Respiratory Medicine, Respiratory Center Toranomon Hospital Tokyo JapanDepartment of Respiratory Medicine, Respiratory Center Toranomon Hospital Tokyo JapanDepartment of Respiratory Medicine, Respiratory Center Toranomon Hospital Tokyo JapanPathological transformation to squamous cell carcinoma after epidermal growth factor receptor (EGFR)‐tyrosine kinase inhibitor treatment has been reported, but details of the transformation remain unclear. We report two cases with transformation to squamous cell carcinoma. The first case was a 61‐year‐old man who was an ex‐smoker with stage IV lung adenocarcinoma harbouring EGFR exon 19 insertion. He experienced squamous cell transformation after 28 months of erlotinib therapy. Next‐generation sequencing (NGS) analysis showed EGFR T790M and genomic alterations in PTEN, PDGFR, and HRAS. The second case was a 72‐year‐old man who was an ex‐smoker with stage IV lung adenocarcinoma harbouring EGFR exon 21 L858R. He experienced squamous cell transformation after nine months of erlotinib therapy. NGS analysis showed EGFR T790M and genomic alterations in PTEN, SMARCB1, TP53, and KIT. Both patients had PTEN genomic alterations and the PI3K/AKT/mTOR (mammalian target of rapamycin) pathway might play an important role in squamous cell transformation.https://doi.org/10.1002/rcr2.521Epidermal growth factor receptor‐tyrosine kinase inhibitornon‐small cell lung cancerPI3K/AKT/mTORPTENsquamous cell transformation |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Hironori Uruga Takeshi Fujii Nobuyuki Nakamura Shuhei Moriguchi Kazuma Kishi Hisashi Takaya |
spellingShingle |
Hironori Uruga Takeshi Fujii Nobuyuki Nakamura Shuhei Moriguchi Kazuma Kishi Hisashi Takaya Squamous cell transformation as a mechanism of acquired resistance to tyrosine kinase inhibitor in EGFR‐mutated lung adenocarcinoma: a report of two cases Respirology Case Reports Epidermal growth factor receptor‐tyrosine kinase inhibitor non‐small cell lung cancer PI3K/AKT/mTOR PTEN squamous cell transformation |
author_facet |
Hironori Uruga Takeshi Fujii Nobuyuki Nakamura Shuhei Moriguchi Kazuma Kishi Hisashi Takaya |
author_sort |
Hironori Uruga |
title |
Squamous cell transformation as a mechanism of acquired resistance to tyrosine kinase inhibitor in EGFR‐mutated lung adenocarcinoma: a report of two cases |
title_short |
Squamous cell transformation as a mechanism of acquired resistance to tyrosine kinase inhibitor in EGFR‐mutated lung adenocarcinoma: a report of two cases |
title_full |
Squamous cell transformation as a mechanism of acquired resistance to tyrosine kinase inhibitor in EGFR‐mutated lung adenocarcinoma: a report of two cases |
title_fullStr |
Squamous cell transformation as a mechanism of acquired resistance to tyrosine kinase inhibitor in EGFR‐mutated lung adenocarcinoma: a report of two cases |
title_full_unstemmed |
Squamous cell transformation as a mechanism of acquired resistance to tyrosine kinase inhibitor in EGFR‐mutated lung adenocarcinoma: a report of two cases |
title_sort |
squamous cell transformation as a mechanism of acquired resistance to tyrosine kinase inhibitor in egfr‐mutated lung adenocarcinoma: a report of two cases |
publisher |
Wiley |
series |
Respirology Case Reports |
issn |
2051-3380 |
publishDate |
2020-03-01 |
description |
Pathological transformation to squamous cell carcinoma after epidermal growth factor receptor (EGFR)‐tyrosine kinase inhibitor treatment has been reported, but details of the transformation remain unclear. We report two cases with transformation to squamous cell carcinoma. The first case was a 61‐year‐old man who was an ex‐smoker with stage IV lung adenocarcinoma harbouring EGFR exon 19 insertion. He experienced squamous cell transformation after 28 months of erlotinib therapy. Next‐generation sequencing (NGS) analysis showed EGFR T790M and genomic alterations in PTEN, PDGFR, and HRAS. The second case was a 72‐year‐old man who was an ex‐smoker with stage IV lung adenocarcinoma harbouring EGFR exon 21 L858R. He experienced squamous cell transformation after nine months of erlotinib therapy. NGS analysis showed EGFR T790M and genomic alterations in PTEN, SMARCB1, TP53, and KIT. Both patients had PTEN genomic alterations and the PI3K/AKT/mTOR (mammalian target of rapamycin) pathway might play an important role in squamous cell transformation. |
topic |
Epidermal growth factor receptor‐tyrosine kinase inhibitor non‐small cell lung cancer PI3K/AKT/mTOR PTEN squamous cell transformation |
url |
https://doi.org/10.1002/rcr2.521 |
work_keys_str_mv |
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