Association between Helicobacter pylori infection and cognitive impairment in the elderly
Background/purpose: Helicobacter pylori (H. pylori) infection has been positively associated with cognitive impairment. However, previous studies have shown inconsistent findings. Methods: This cross-sectional study included 587 elderly participants (age ≧ 65) from the annual elderly health checkup...
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doaj-02bea3878579473aa1eee8b8883727282020-11-24T21:44:57ZengElsevierJournal of the Formosan Medical Association0929-66462018-11-01117119941002Association between Helicobacter pylori infection and cognitive impairment in the elderlyMing-Lun Han0Jen-Hau Chen1Min-Kuang Tsai2Jyh-Ming Liou3Jeng-Min Chiou4Ming-Jang Chiu5Yen-Ching Chen6Department of Internal Medicine, Min-Sheng General Hospital, Taoyuan, Taiwan; Institute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taipei, TaiwanInstitute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taipei, Taiwan; Department of Geriatrics and Gerontology, National Taiwan University Hospital, Taipei, TaiwanInstitute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taipei, TaiwanDepartment of Internal Medicine, National Taiwan University Hospital, Taipei, TaiwanInstitute of Statistical Science, Academia Sinica, Taipei, TaiwanDepartment of Neurology, National Taiwan University Hospital, Taipei, TaiwanInstitute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taipei, Taiwan; Department of Public Health, College of Public Health, National Taiwan University, Taipei, Taiwan; Research Center for Genes, Environment and Human Health, College of Public Health, National Taiwan University, Taipei, Taiwan; Corresponding author. Dr. Yen-Ching Chen, Institute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, No.17 Xu-Zhou Road, Taipei 10055, Taiwan. Fax: +886 2 2351 1955.Background/purpose: Helicobacter pylori (H. pylori) infection has been positively associated with cognitive impairment. However, previous studies have shown inconsistent findings. Methods: This cross-sectional study included 587 elderly participants (age ≧ 65) from the annual elderly health checkup program at the National Taiwan University Hospital from 2011 to 2013. Both global and domain-specific cognition were assessed using various neuropsychiatric tests. Multivariable linear regression and logistic regression models were utilized to assess the association between the serum H. pylori IgG level and cognitive impairment. Results: Compared with the lowest quartile of H. pylori IgG (Q1), the highest quartile (Q4) was associated with lower scores on verbal fluency-vegetables (β = −0.24), domain-specific attention [digit span-forward: β = −0.19; odds ratio (OR) = 1.83, 95% confidence interval (CI) = 1.03–3.24], and attention factors (β = −0.20; OR= 2.67, 95% CI = 1.51–4.73). No significant association was observed for global cognition. Stratified analyses revealed that, among men, the highest quartile of serum H. pylori IgG (Q4) was associated with impaired scores on verbal fluency-vegetables (β = −0.38; OR = 3.01, 95% CI = 1.42–6.38). Conclusion: Our findings disclosed a positive association between serum H. pylori level and cognitive impairment, which provides important information for the primary prevention of cognitive impairment through the eradication of H. pylori. Keywords: Helicobacter pylori, Infection, Cognitive impairment, Eldershttp://www.sciencedirect.com/science/article/pii/S0929664617306241 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Ming-Lun Han Jen-Hau Chen Min-Kuang Tsai Jyh-Ming Liou Jeng-Min Chiou Ming-Jang Chiu Yen-Ching Chen |
spellingShingle |
Ming-Lun Han Jen-Hau Chen Min-Kuang Tsai Jyh-Ming Liou Jeng-Min Chiou Ming-Jang Chiu Yen-Ching Chen Association between Helicobacter pylori infection and cognitive impairment in the elderly Journal of the Formosan Medical Association |
author_facet |
Ming-Lun Han Jen-Hau Chen Min-Kuang Tsai Jyh-Ming Liou Jeng-Min Chiou Ming-Jang Chiu Yen-Ching Chen |
author_sort |
Ming-Lun Han |
title |
Association between Helicobacter pylori infection and cognitive impairment in the elderly |
title_short |
Association between Helicobacter pylori infection and cognitive impairment in the elderly |
title_full |
Association between Helicobacter pylori infection and cognitive impairment in the elderly |
title_fullStr |
Association between Helicobacter pylori infection and cognitive impairment in the elderly |
title_full_unstemmed |
Association between Helicobacter pylori infection and cognitive impairment in the elderly |
title_sort |
association between helicobacter pylori infection and cognitive impairment in the elderly |
publisher |
Elsevier |
series |
Journal of the Formosan Medical Association |
issn |
0929-6646 |
publishDate |
2018-11-01 |
description |
Background/purpose: Helicobacter pylori (H. pylori) infection has been positively associated with cognitive impairment. However, previous studies have shown inconsistent findings. Methods: This cross-sectional study included 587 elderly participants (age ≧ 65) from the annual elderly health checkup program at the National Taiwan University Hospital from 2011 to 2013. Both global and domain-specific cognition were assessed using various neuropsychiatric tests. Multivariable linear regression and logistic regression models were utilized to assess the association between the serum H. pylori IgG level and cognitive impairment. Results: Compared with the lowest quartile of H. pylori IgG (Q1), the highest quartile (Q4) was associated with lower scores on verbal fluency-vegetables (β = −0.24), domain-specific attention [digit span-forward: β = −0.19; odds ratio (OR) = 1.83, 95% confidence interval (CI) = 1.03–3.24], and attention factors (β = −0.20; OR= 2.67, 95% CI = 1.51–4.73). No significant association was observed for global cognition. Stratified analyses revealed that, among men, the highest quartile of serum H. pylori IgG (Q4) was associated with impaired scores on verbal fluency-vegetables (β = −0.38; OR = 3.01, 95% CI = 1.42–6.38). Conclusion: Our findings disclosed a positive association between serum H. pylori level and cognitive impairment, which provides important information for the primary prevention of cognitive impairment through the eradication of H. pylori. Keywords: Helicobacter pylori, Infection, Cognitive impairment, Elders |
url |
http://www.sciencedirect.com/science/article/pii/S0929664617306241 |
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