Estrone-3-Sulfate Stimulates the Proliferation of T47D Breast Cancer Cells Stably Transfected With the Sodium-Dependent Organic Anion Transporter SOAT (SLC10A6)

Estrone-3-Sulfate Stimulates the Proliferation of T47D Breast Cancer Cells Stably Transfected With the Sodium-Dependent Organic Anion Transporter SOAT (SLC10A6)

Estrogens play a pivotal role in the development and proliferation of hormone-dependent breast cancer. Apart from free estrogens, which can directly activate the estrogen receptor (ER) of tumor cells, sulfo-conjugated steroids, which maintain high plasma concentrations even after menopause, first ha...

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Bibliographic Details
Main Authors: Emre Karakus, Daniel Zahner, Gary Grosser, Regina Leidolf, Cemal Gundogdu, Alberto Sánchez-Guijo, Stefan A. Wudy, Joachim Geyer
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-08-01
Series:Frontiers in Pharmacology
Subjects:
estrone-3-sulfate
T47D
breast cancer
SOAT
transport
proliferation
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2018.00941/full

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