Periostin Mediates Right Ventricular Failure through Induction of Inducible Nitric Oxide Synthase Expression in Right Ventricular Fibroblasts from Monocrotaline-Induced Pulmonary Arterial Hypertensive Rats

Periostin Mediates Right Ventricular Failure through Induction of Inducible Nitric Oxide Synthase Expression in Right Ventricular Fibroblasts from Monocrotaline-Induced Pulmonary Arterial Hypertensive Rats

Pulmonary arterial hypertension (PAH) leads to lethal right ventricular failure (RVF). Periostin (POSTN) mRNA expression is increased in right ventricles (RVs) of monocrotaline (MCT)-induced PAH model rats. However, the pathophysiological role of POSTN in RVF has not been clarified. We investigated...

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Bibliographic Details
Main Authors: Keisuke Imoto, Muneyoshi Okada, Hideyuki Yamawaki
Format: Article
Language:English
Published: MDPI AG 2018-12-01
Series:International Journal of Molecular Sciences
Subjects:
pulmonary arterial hypertension
monocrotaline
right ventricular failure
nitric oxide
inducible nitric oxide synthase
periostin
right ventricular fibroblasts
">l-type Ca2+ channel
Online Access:http://www.mdpi.com/1422-0067/20/1/62

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http://www.mdpi.com/1422-0067/20/1/62

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