Prevention of lipopolysaccharide-induced preterm labor by the lack of CX3CL1-CX3CR1 interaction in mice.
Preterm labor (PTL) is the most common cause of neonatal death and long-term adverse outcome. The pharmacological agents for PTL prevention are palliative and frequently fail to prevent PTL and improve neonatal outcome. It is essential to fully understand the molecular mechanisms of PTL in order to...
Main Authors: | , , , , , , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2018-01-01
|
Series: | PLoS ONE |
Online Access: | http://europepmc.org/articles/PMC6219809?pdf=render |
id |
doaj-02e6ddffaca2434aa8fd4aa6397d8003 |
---|---|
record_format |
Article |
spelling |
doaj-02e6ddffaca2434aa8fd4aa6397d80032020-11-25T01:04:30ZengPublic Library of Science (PLoS)PLoS ONE1932-62032018-01-011311e020708510.1371/journal.pone.0207085Prevention of lipopolysaccharide-induced preterm labor by the lack of CX3CL1-CX3CR1 interaction in mice.Mika MizoguchiYuko IshidaMizuho NosakaAkihiko KimuraYumi KuninakaTamaki YahataSakiko NanjoSaori ToujimaSawako MinamiKazuhiko InoNaofumi MukaidaToshikazu KondoPreterm labor (PTL) is the most common cause of neonatal death and long-term adverse outcome. The pharmacological agents for PTL prevention are palliative and frequently fail to prevent PTL and improve neonatal outcome. It is essential to fully understand the molecular mechanisms of PTL in order to develop novel therapeutic methods against PTL. Several lines of evidence indicate some chemokines are expressed in gestational tissues during labor or PTL. To reveal the pathophysiological roles of the CX3CL1-CX3CR1 axis in PTL, we performed present study using LPS-induced PTL mice model in CX3CR1-deficient (Cx3cr1-/-) mice. We indicated that PTL was suppressed in Cx3cr1-/- mice and immunoneutralization of CX3CL1 in WT mice. From immunohistochemical and the gene expression analyses, the CX3CL1-CX3CR1 axis has detrimental roles in PTL through intrauterine recruitment of macrophages and the enhancement of macrophage-derived inflammatory mediators. Thus, the CX3CL1-CX3CR1 axis may be a good molecular target for preventing PTL.http://europepmc.org/articles/PMC6219809?pdf=render |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Mika Mizoguchi Yuko Ishida Mizuho Nosaka Akihiko Kimura Yumi Kuninaka Tamaki Yahata Sakiko Nanjo Saori Toujima Sawako Minami Kazuhiko Ino Naofumi Mukaida Toshikazu Kondo |
spellingShingle |
Mika Mizoguchi Yuko Ishida Mizuho Nosaka Akihiko Kimura Yumi Kuninaka Tamaki Yahata Sakiko Nanjo Saori Toujima Sawako Minami Kazuhiko Ino Naofumi Mukaida Toshikazu Kondo Prevention of lipopolysaccharide-induced preterm labor by the lack of CX3CL1-CX3CR1 interaction in mice. PLoS ONE |
author_facet |
Mika Mizoguchi Yuko Ishida Mizuho Nosaka Akihiko Kimura Yumi Kuninaka Tamaki Yahata Sakiko Nanjo Saori Toujima Sawako Minami Kazuhiko Ino Naofumi Mukaida Toshikazu Kondo |
author_sort |
Mika Mizoguchi |
title |
Prevention of lipopolysaccharide-induced preterm labor by the lack of CX3CL1-CX3CR1 interaction in mice. |
title_short |
Prevention of lipopolysaccharide-induced preterm labor by the lack of CX3CL1-CX3CR1 interaction in mice. |
title_full |
Prevention of lipopolysaccharide-induced preterm labor by the lack of CX3CL1-CX3CR1 interaction in mice. |
title_fullStr |
Prevention of lipopolysaccharide-induced preterm labor by the lack of CX3CL1-CX3CR1 interaction in mice. |
title_full_unstemmed |
Prevention of lipopolysaccharide-induced preterm labor by the lack of CX3CL1-CX3CR1 interaction in mice. |
title_sort |
prevention of lipopolysaccharide-induced preterm labor by the lack of cx3cl1-cx3cr1 interaction in mice. |
publisher |
Public Library of Science (PLoS) |
series |
PLoS ONE |
issn |
1932-6203 |
publishDate |
2018-01-01 |
description |
Preterm labor (PTL) is the most common cause of neonatal death and long-term adverse outcome. The pharmacological agents for PTL prevention are palliative and frequently fail to prevent PTL and improve neonatal outcome. It is essential to fully understand the molecular mechanisms of PTL in order to develop novel therapeutic methods against PTL. Several lines of evidence indicate some chemokines are expressed in gestational tissues during labor or PTL. To reveal the pathophysiological roles of the CX3CL1-CX3CR1 axis in PTL, we performed present study using LPS-induced PTL mice model in CX3CR1-deficient (Cx3cr1-/-) mice. We indicated that PTL was suppressed in Cx3cr1-/- mice and immunoneutralization of CX3CL1 in WT mice. From immunohistochemical and the gene expression analyses, the CX3CL1-CX3CR1 axis has detrimental roles in PTL through intrauterine recruitment of macrophages and the enhancement of macrophage-derived inflammatory mediators. Thus, the CX3CL1-CX3CR1 axis may be a good molecular target for preventing PTL. |
url |
http://europepmc.org/articles/PMC6219809?pdf=render |
work_keys_str_mv |
AT mikamizoguchi preventionoflipopolysaccharideinducedpretermlaborbythelackofcx3cl1cx3cr1interactioninmice AT yukoishida preventionoflipopolysaccharideinducedpretermlaborbythelackofcx3cl1cx3cr1interactioninmice AT mizuhonosaka preventionoflipopolysaccharideinducedpretermlaborbythelackofcx3cl1cx3cr1interactioninmice AT akihikokimura preventionoflipopolysaccharideinducedpretermlaborbythelackofcx3cl1cx3cr1interactioninmice AT yumikuninaka preventionoflipopolysaccharideinducedpretermlaborbythelackofcx3cl1cx3cr1interactioninmice AT tamakiyahata preventionoflipopolysaccharideinducedpretermlaborbythelackofcx3cl1cx3cr1interactioninmice AT sakikonanjo preventionoflipopolysaccharideinducedpretermlaborbythelackofcx3cl1cx3cr1interactioninmice AT saoritoujima preventionoflipopolysaccharideinducedpretermlaborbythelackofcx3cl1cx3cr1interactioninmice AT sawakominami preventionoflipopolysaccharideinducedpretermlaborbythelackofcx3cl1cx3cr1interactioninmice AT kazuhikoino preventionoflipopolysaccharideinducedpretermlaborbythelackofcx3cl1cx3cr1interactioninmice AT naofumimukaida preventionoflipopolysaccharideinducedpretermlaborbythelackofcx3cl1cx3cr1interactioninmice AT toshikazukondo preventionoflipopolysaccharideinducedpretermlaborbythelackofcx3cl1cx3cr1interactioninmice |
_version_ |
1725197586931908608 |