A systematic exploration of parameters affecting evoked intracranial potentials in patients with epilepsy
Background: Brain activity is constrained by and evolves over a network of structural and functional connections. Corticocortical evoked potentials (CCEPs) have been used to measure this connectivity and to discern brain areas involved in both brain function and disease. However, how varying stimula...
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doaj-02f1e44797974bc89d9da0fbf59be2592021-03-19T07:22:16ZengElsevierBrain Stimulation1935-861X2020-09-0113512321244A systematic exploration of parameters affecting evoked intracranial potentials in patients with epilepsyBornali Kundu0Tyler S. Davis1Brian Philip2Elliot H. Smith3Amir Arain4Angela Peters5Blake Newman6Christopher R. Butson7John D. Rolston8Department of Neurosurgery, Clinical Neurosciences Center, University of Utah, Salt Lake City, UT, USADepartment of Neurosurgery, Clinical Neurosciences Center, University of Utah, Salt Lake City, UT, USADepartment of Biomedical Engineering, University of Utah, Salt Lake City, UT, USADepartment of Neurosurgery, Clinical Neurosciences Center, University of Utah, Salt Lake City, UT, USADepartment of Neurology, Clinical Neurosciences Center, University of Utah, Salt Lake City, UT, USADepartment of Neurology, Clinical Neurosciences Center, University of Utah, Salt Lake City, UT, USADepartment of Neurology, Clinical Neurosciences Center, University of Utah, Salt Lake City, UT, USADepartment of Neurosurgery, Clinical Neurosciences Center, University of Utah, Salt Lake City, UT, USA; Department of Biomedical Engineering, University of Utah, Salt Lake City, UT, USA; Scientific Computing and Imaging Institute, University of Utah, Salt Lake City, UT, USADepartment of Neurosurgery, Clinical Neurosciences Center, University of Utah, Salt Lake City, UT, USA; Department of Biomedical Engineering, University of Utah, Salt Lake City, UT, USA; Scientific Computing and Imaging Institute, University of Utah, Salt Lake City, UT, USA; Corresponding author. Department of Neurosurgery, Clinical Neurosciences Center, University of Utah, 175 N. Medical Drive East, Salt Lake City, UT, 84132, USA.Background: Brain activity is constrained by and evolves over a network of structural and functional connections. Corticocortical evoked potentials (CCEPs) have been used to measure this connectivity and to discern brain areas involved in both brain function and disease. However, how varying stimulation parameters influences the measured CCEP across brain areas has not been well characterized. Objective: To better understand the factors that influence the amplitude of the CCEPs as well as evoked gamma-band power (70–150 Hz) resulting from single-pulse stimulation via cortical surface and depth electrodes. Methods: CCEPs from 4370 stimulation-response channel pairs were recorded across a range of stimulation parameters and brain regions in 11 patients undergoing long-term monitoring for epilepsy. A generalized mixed-effects model was used to model cortical response amplitudes from 5 to 100 ms post-stimulation. Results: Stimulation levels <5.5 mA generated variable CCEPs with low amplitude and reduced spatial spread. Stimulation at ≥5.5 mA yielded a reliable and maximal CCEP across stimulation-response pairs over all regions. These findings were similar when examining the evoked gamma-band power. The amplitude of both measures was inversely correlated with distance. CCEPs and evoked gamma power were largest when measured in the hippocampus compared with other areas. Larger CCEP size and evoked gamma power were measured within the seizure onset zone compared with outside this zone. Conclusion: These results will help guide future stimulation protocols directed at quantifying network connectivity across cognitive and disease states.http://www.sciencedirect.com/science/article/pii/S1935861X20301200Corticocortical evoked potential (CCEP)Stereoelectroencephalography (SEEG)GammaPowerSingle-pulse electrical stimulation (SPES) |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Bornali Kundu Tyler S. Davis Brian Philip Elliot H. Smith Amir Arain Angela Peters Blake Newman Christopher R. Butson John D. Rolston |
spellingShingle |
Bornali Kundu Tyler S. Davis Brian Philip Elliot H. Smith Amir Arain Angela Peters Blake Newman Christopher R. Butson John D. Rolston A systematic exploration of parameters affecting evoked intracranial potentials in patients with epilepsy Brain Stimulation Corticocortical evoked potential (CCEP) Stereoelectroencephalography (SEEG) Gamma Power Single-pulse electrical stimulation (SPES) |
author_facet |
Bornali Kundu Tyler S. Davis Brian Philip Elliot H. Smith Amir Arain Angela Peters Blake Newman Christopher R. Butson John D. Rolston |
author_sort |
Bornali Kundu |
title |
A systematic exploration of parameters affecting evoked intracranial potentials in patients with epilepsy |
title_short |
A systematic exploration of parameters affecting evoked intracranial potentials in patients with epilepsy |
title_full |
A systematic exploration of parameters affecting evoked intracranial potentials in patients with epilepsy |
title_fullStr |
A systematic exploration of parameters affecting evoked intracranial potentials in patients with epilepsy |
title_full_unstemmed |
A systematic exploration of parameters affecting evoked intracranial potentials in patients with epilepsy |
title_sort |
systematic exploration of parameters affecting evoked intracranial potentials in patients with epilepsy |
publisher |
Elsevier |
series |
Brain Stimulation |
issn |
1935-861X |
publishDate |
2020-09-01 |
description |
Background: Brain activity is constrained by and evolves over a network of structural and functional connections. Corticocortical evoked potentials (CCEPs) have been used to measure this connectivity and to discern brain areas involved in both brain function and disease. However, how varying stimulation parameters influences the measured CCEP across brain areas has not been well characterized. Objective: To better understand the factors that influence the amplitude of the CCEPs as well as evoked gamma-band power (70–150 Hz) resulting from single-pulse stimulation via cortical surface and depth electrodes. Methods: CCEPs from 4370 stimulation-response channel pairs were recorded across a range of stimulation parameters and brain regions in 11 patients undergoing long-term monitoring for epilepsy. A generalized mixed-effects model was used to model cortical response amplitudes from 5 to 100 ms post-stimulation. Results: Stimulation levels <5.5 mA generated variable CCEPs with low amplitude and reduced spatial spread. Stimulation at ≥5.5 mA yielded a reliable and maximal CCEP across stimulation-response pairs over all regions. These findings were similar when examining the evoked gamma-band power. The amplitude of both measures was inversely correlated with distance. CCEPs and evoked gamma power were largest when measured in the hippocampus compared with other areas. Larger CCEP size and evoked gamma power were measured within the seizure onset zone compared with outside this zone. Conclusion: These results will help guide future stimulation protocols directed at quantifying network connectivity across cognitive and disease states. |
topic |
Corticocortical evoked potential (CCEP) Stereoelectroencephalography (SEEG) Gamma Power Single-pulse electrical stimulation (SPES) |
url |
http://www.sciencedirect.com/science/article/pii/S1935861X20301200 |
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