Extended Interneuronal Network of the Dentate Gyrus

Local interneurons control principal cells within individual brain areas, but anecdotal observations indicate that interneuronal axons sometimes extend beyond strict anatomical boundaries. Here, we use the case of the dentate gyrus (DG) to show that boundary-crossing interneurons with cell bodies in...

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Main Authors:	Gergely G. Szabo, Xi Du, Mikko Oijala, Csaba Varga, Jack M. Parent, Ivan Soltesz
Format:	Article
Language:	English
Published:	Elsevier 2017-08-01
Series:	Cell Reports
Subjects:	GABA inhibition hippocampus network
Online Access:	http://www.sciencedirect.com/science/article/pii/S2211124717310082

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spelling	doaj-02f3123e50b643aba3f2281bc7cbae2d2020-11-25T01:32:29ZengElsevierCell Reports2211-12472017-08-012061262126810.1016/j.celrep.2017.07.042Extended Interneuronal Network of the Dentate GyrusGergely G. Szabo0Xi Du1Mikko Oijala2Csaba Varga3Jack M. Parent4Ivan Soltesz5Department of Neurosurgery, Stanford University, Stanford, CA 94305, USANeuroscience Graduate Program, Medical Scientist Training Program, University of Michigan, Ann Arbor, MI 48109, USADepartment of Neurosurgery, Stanford University, Stanford, CA 94305, USADepartment of Neurosurgery, Stanford University, Stanford, CA 94305, USANeuroscience Graduate Program, Medical Scientist Training Program, University of Michigan, Ann Arbor, MI 48109, USADepartment of Neurosurgery, Stanford University, Stanford, CA 94305, USALocal interneurons control principal cells within individual brain areas, but anecdotal observations indicate that interneuronal axons sometimes extend beyond strict anatomical boundaries. Here, we use the case of the dentate gyrus (DG) to show that boundary-crossing interneurons with cell bodies in CA3 and CA1 constitute a numerically significant and diverse population that relays patterns of activity generated within the CA regions back to granule cells. These results reveal the existence of a sophisticated retrograde GABAergic circuit that fundamentally extends the canonical interneuronal network.http://www.sciencedirect.com/science/article/pii/S2211124717310082GABAinhibitionhippocampusnetwork
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Gergely G. Szabo Xi Du Mikko Oijala Csaba Varga Jack M. Parent Ivan Soltesz
spellingShingle	Gergely G. Szabo Xi Du Mikko Oijala Csaba Varga Jack M. Parent Ivan Soltesz Extended Interneuronal Network of the Dentate Gyrus Cell Reports GABA inhibition hippocampus network
author_facet	Gergely G. Szabo Xi Du Mikko Oijala Csaba Varga Jack M. Parent Ivan Soltesz
author_sort	Gergely G. Szabo
title	Extended Interneuronal Network of the Dentate Gyrus
title_short	Extended Interneuronal Network of the Dentate Gyrus
title_full	Extended Interneuronal Network of the Dentate Gyrus
title_fullStr	Extended Interneuronal Network of the Dentate Gyrus
title_full_unstemmed	Extended Interneuronal Network of the Dentate Gyrus
title_sort	extended interneuronal network of the dentate gyrus
publisher	Elsevier
series	Cell Reports
issn	2211-1247
publishDate	2017-08-01
description	Local interneurons control principal cells within individual brain areas, but anecdotal observations indicate that interneuronal axons sometimes extend beyond strict anatomical boundaries. Here, we use the case of the dentate gyrus (DG) to show that boundary-crossing interneurons with cell bodies in CA3 and CA1 constitute a numerically significant and diverse population that relays patterns of activity generated within the CA regions back to granule cells. These results reveal the existence of a sophisticated retrograde GABAergic circuit that fundamentally extends the canonical interneuronal network.
topic	GABA inhibition hippocampus network
url	http://www.sciencedirect.com/science/article/pii/S2211124717310082
work_keys_str_mv	AT gergelygszabo extendedinterneuronalnetworkofthedentategyrus AT xidu extendedinterneuronalnetworkofthedentategyrus AT mikkooijala extendedinterneuronalnetworkofthedentategyrus AT csabavarga extendedinterneuronalnetworkofthedentategyrus AT jackmparent extendedinterneuronalnetworkofthedentategyrus AT ivansoltesz extendedinterneuronalnetworkofthedentategyrus
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Extended Interneuronal Network of the Dentate Gyrus

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