Inflammaging and Complement System: A Link Between Acute Kidney Injury and Chronic Graft Damage

Inflammaging and Complement System: A Link Between Acute Kidney Injury and Chronic Graft Damage

The aberrant activation of complement system in several kidney diseases suggests that this pillar of innate immunity has a critical role in the pathophysiology of renal damage of different etiologies. A growing body of experimental evidence indicates that complement activation contributes to the pat...

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Bibliographic Details
Main Authors: Rossana Franzin, Alessandra Stasi, Marco Fiorentino, Giovanni Stallone, Vincenzo Cantaluppi, Loreto Gesualdo, Giuseppe Castellano
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-05-01
Series:Frontiers in Immunology
Subjects:
renal aging
complement system
AKI-to-CKD transition
cellular senescence and SASP
complement inhibition therapy
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.00734/full

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