Neuroimaging Correlates of Cognitive Dysfunction in Adults with Multiple Sclerosis

Neuroimaging Correlates of Cognitive Dysfunction in Adults with Multiple Sclerosis

Cognitive impairment is a frequent and meaningful symptom in multiple sclerosis (MS), caused by the accrual of brain structural damage only partially counteracted by effective functional reorganization. As both these aspects can be successfully investigated through the application of advanced neuroi...

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Bibliographic Details
Main Authors: Maria Petracca, Giuseppe Pontillo, Marcello Moccia, Antonio Carotenuto, Sirio Cocozza, Roberta Lanzillo, Arturo Brunetti, Vincenzo Brescia Morra
Format: Article
Language:English
Published: MDPI AG 2021-03-01
Series:Brain Sciences
Subjects:
cognitive dysfunction
neuroimaging
multiple sclerosis
magnetic resonance imaging
positron emission tomography
sodium
Online Access:https://www.mdpi.com/2076-3425/11/3/346
Description
Summary:Cognitive impairment is a frequent and meaningful symptom in multiple sclerosis (MS), caused by the accrual of brain structural damage only partially counteracted by effective functional reorganization. As both these aspects can be successfully investigated through the application of advanced neuroimaging, here, we offer an up-to-date overview of the latest findings on structural, functional and metabolic correlates of cognitive impairment in adults with MS, focusing on the mechanisms sustaining damage accrual and on the identification of useful imaging markers of cognitive decline.
ISSN:2076-3425

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