The association between reflux esophagitis and airway hyper-reactivity in patients with gastro-esophageal reflux
Background: The association of gastro-esophageal reflux (GER) with a wide variety of pulmonary disorders was recognized. We aimed to evaluate the effect of GER-induced esophagitis on airway hyper-reactivity (AHR) in patients and the response to treatment. Materials and Methods: In this cohort study,...
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doaj-02ff1b29bd3349339bb87354e349d5072020-11-25T01:01:05ZengWolters Kluwer Medknow PublicationsJournal of Research in Medical Sciences1735-19951735-71362013-01-01186473476The association between reflux esophagitis and airway hyper-reactivity in patients with gastro-esophageal refluxAshraf KarbasiMohammad Emami ArdestaniMostafa GhaneiAli Amini HarandiBackground: The association of gastro-esophageal reflux (GER) with a wide variety of pulmonary disorders was recognized. We aimed to evaluate the effect of GER-induced esophagitis on airway hyper-reactivity (AHR) in patients and the response to treatment. Materials and Methods: In this cohort study, 30 patients attending the gastrointestinal clinic of a university hospital with acid reflux symptoms were included. All patients were evaluated endoscopically and divided into case group with esophagitis and control group without any evidence of esophagitis. Spirometry and methacholine test were done in all patients before and after treatment of GER with pantoprazole 40 mg daily for six months. Results: There was a significant difference in the rate of positive methacholine test between the cases (40%) and the controls (6.7%) prior to anti-acid therapy (P < 0.0001). After six months of treatment, the frequency of positive methacholine test diminished from 40 to 13.3% in the case group (P < 0.05) but did not change in the controls (P = 0.15). Conclusion: The presence of esophagitis due to GER would increase the AHR and treatment with pantoperazole would decrease AHR in patients with proved esophagitis and no previous history of asthma after six months.http://www.jmsjournal.net/article.asp?issn=1735-1995;year=2013;volume=18;issue=6;spage=473;epage=476;aulast=KarbasiAirway hyper-reactivitygastroesophageal refluxmethacholine testspirometry |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Ashraf Karbasi Mohammad Emami Ardestani Mostafa Ghanei Ali Amini Harandi |
spellingShingle |
Ashraf Karbasi Mohammad Emami Ardestani Mostafa Ghanei Ali Amini Harandi The association between reflux esophagitis and airway hyper-reactivity in patients with gastro-esophageal reflux Journal of Research in Medical Sciences Airway hyper-reactivity gastroesophageal reflux methacholine test spirometry |
author_facet |
Ashraf Karbasi Mohammad Emami Ardestani Mostafa Ghanei Ali Amini Harandi |
author_sort |
Ashraf Karbasi |
title |
The association between reflux esophagitis and airway hyper-reactivity in patients with gastro-esophageal reflux |
title_short |
The association between reflux esophagitis and airway hyper-reactivity in patients with gastro-esophageal reflux |
title_full |
The association between reflux esophagitis and airway hyper-reactivity in patients with gastro-esophageal reflux |
title_fullStr |
The association between reflux esophagitis and airway hyper-reactivity in patients with gastro-esophageal reflux |
title_full_unstemmed |
The association between reflux esophagitis and airway hyper-reactivity in patients with gastro-esophageal reflux |
title_sort |
association between reflux esophagitis and airway hyper-reactivity in patients with gastro-esophageal reflux |
publisher |
Wolters Kluwer Medknow Publications |
series |
Journal of Research in Medical Sciences |
issn |
1735-1995 1735-7136 |
publishDate |
2013-01-01 |
description |
Background: The association of gastro-esophageal reflux (GER) with a wide variety of pulmonary disorders was recognized. We aimed to evaluate the effect of GER-induced esophagitis on airway hyper-reactivity (AHR) in patients and the response to treatment. Materials and Methods: In this cohort study, 30 patients attending the gastrointestinal clinic of a university hospital with acid reflux symptoms were included. All patients were evaluated endoscopically and divided into case group with esophagitis and control group without any evidence of esophagitis. Spirometry and methacholine test were done in all patients before and after treatment of GER with pantoprazole 40 mg daily for six months. Results: There was a significant difference in the rate of positive methacholine test between the cases (40%) and the controls (6.7%) prior to anti-acid therapy (P < 0.0001). After six months of treatment, the frequency of positive methacholine test diminished from 40 to 13.3% in the case group (P < 0.05) but did not change in the controls (P = 0.15).
Conclusion: The presence of esophagitis due to GER would increase the AHR and treatment with pantoperazole would decrease AHR in patients with proved esophagitis and no previous history of asthma after six months. |
topic |
Airway hyper-reactivity gastroesophageal reflux methacholine test spirometry |
url |
http://www.jmsjournal.net/article.asp?issn=1735-1995;year=2013;volume=18;issue=6;spage=473;epage=476;aulast=Karbasi |
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