Tissue resident and follicular Treg cell differentiation is regulated by CRAC channels

Tissue resident and follicular Treg cell differentiation is regulated by CRAC channels

Regulatory T (Treg) cells are important for maintaining immune homeostasis. Here the authors show that STIM1 and STIM2, which activate the Ca2+ channel ORAI1, are essential for the differentiation of peripheral Treg cells into tissue-resident and follicular Treg cells and their ability to limit auto...

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Main Authors: Martin Vaeth, Yin-Hu Wang, Miriam Eckstein, Jun Yang, Gregg J. Silverman, Rodrigo S. Lacruz, Kasthuri Kannan, Stefan Feske
Format: Article
Language:English
Published: Nature Publishing Group 2019-03-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-08959-8
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spelling doaj-0300d7db026b4d60913b2983240f24ef2021-05-11T12:17:42ZengNature Publishing GroupNature Communications2041-17232019-03-0110111610.1038/s41467-019-08959-8Tissue resident and follicular Treg cell differentiation is regulated by CRAC channelsMartin Vaeth0Yin-Hu Wang1Miriam Eckstein2Jun Yang3Gregg J. Silverman4Rodrigo S. Lacruz5Kasthuri Kannan6Stefan Feske7Department of Pathology, New York University School of MedicineDepartment of Pathology, New York University School of MedicineDepartment of Basic Science and Craniofacial Biology, New York University College of DentistryDepartment of Pathology, New York University School of MedicineDepartment of Medicine, New York University School of MedicineDepartment of Basic Science and Craniofacial Biology, New York University College of DentistryDepartment of Pathology, New York University School of MedicineDepartment of Pathology, New York University School of MedicineRegulatory T (Treg) cells are important for maintaining immune homeostasis. Here the authors show that STIM1 and STIM2, which activate the Ca2+ channel ORAI1, are essential for the differentiation of peripheral Treg cells into tissue-resident and follicular Treg cells and their ability to limit autoimmunity in mice.https://doi.org/10.1038/s41467-019-08959-8
collection DOAJ
language English
format Article
sources DOAJ
author Martin Vaeth
Yin-Hu Wang
Miriam Eckstein
Jun Yang
Gregg J. Silverman
Rodrigo S. Lacruz
Kasthuri Kannan
Stefan Feske
spellingShingle Martin Vaeth
Yin-Hu Wang
Miriam Eckstein
Jun Yang
Gregg J. Silverman
Rodrigo S. Lacruz
Kasthuri Kannan
Stefan Feske
Tissue resident and follicular Treg cell differentiation is regulated by CRAC channels
Nature Communications
author_facet Martin Vaeth
Yin-Hu Wang
Miriam Eckstein
Jun Yang
Gregg J. Silverman
Rodrigo S. Lacruz
Kasthuri Kannan
Stefan Feske
author_sort Martin Vaeth
title Tissue resident and follicular Treg cell differentiation is regulated by CRAC channels
title_short Tissue resident and follicular Treg cell differentiation is regulated by CRAC channels
title_full Tissue resident and follicular Treg cell differentiation is regulated by CRAC channels
title_fullStr Tissue resident and follicular Treg cell differentiation is regulated by CRAC channels
title_full_unstemmed Tissue resident and follicular Treg cell differentiation is regulated by CRAC channels
title_sort tissue resident and follicular treg cell differentiation is regulated by crac channels
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2019-03-01
description Regulatory T (Treg) cells are important for maintaining immune homeostasis. Here the authors show that STIM1 and STIM2, which activate the Ca2+ channel ORAI1, are essential for the differentiation of peripheral Treg cells into tissue-resident and follicular Treg cells and their ability to limit autoimmunity in mice.
url https://doi.org/10.1038/s41467-019-08959-8
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AT yinhuwang tissueresidentandfolliculartregcelldifferentiationisregulatedbycracchannels
AT miriameckstein tissueresidentandfolliculartregcelldifferentiationisregulatedbycracchannels
AT junyang tissueresidentandfolliculartregcelldifferentiationisregulatedbycracchannels
AT greggjsilverman tissueresidentandfolliculartregcelldifferentiationisregulatedbycracchannels
AT rodrigoslacruz tissueresidentandfolliculartregcelldifferentiationisregulatedbycracchannels
AT kasthurikannan tissueresidentandfolliculartregcelldifferentiationisregulatedbycracchannels
AT stefanfeske tissueresidentandfolliculartregcelldifferentiationisregulatedbycracchannels
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