Design and in vitro/in vivo evaluation of sustained-release floating tablets of itopride hydrochloride
Sayed M Ahmed,1 Adel Ahmed Ali,2 Ahmed MA Ali,2,3 Omiya A Hassan2,4 1Department of Industrial Pharmacy, Faculty of Pharmacy, Assiut University, Assiut, 2Department of Pharmaceutics, Faculty of Pharmacy, Beni-Suef University, Beni-Suef, Egypt; 3Department of Pharmaceutics, Faculty of Pharmacy, Taif...
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doaj-0310af4dc92749bb96842e8eea8d45732020-11-24T23:18:01ZengDove Medical PressDrug Design, Development and Therapy1177-88812016-12-01Volume 104061407130504Design and in vitro/in vivo evaluation of sustained-release floating tablets of itopride hydrochlorideAhmed SMAhmed Ali AAli AMAHassan OASayed M Ahmed,1 Adel Ahmed Ali,2 Ahmed MA Ali,2,3 Omiya A Hassan2,4 1Department of Industrial Pharmacy, Faculty of Pharmacy, Assiut University, Assiut, 2Department of Pharmaceutics, Faculty of Pharmacy, Beni-Suef University, Beni-Suef, Egypt; 3Department of Pharmaceutics, Faculty of Pharmacy, Taif University, Taif, Kingdom of Saudi Arabia; 4Department of Pharmaceutics, Faculty of Pharmacy, Deraya University, El-Minia Gadida, Egypt Purpose: The aim of the present study was to improve the bioavailability of itopride (ITO) and sustain its action by formulating as a floating dosage form. Materials and methods: Sustained-release floating tablets of ITO hydrochloride (HCl) were prepared by direct compression using different hydrocolloid polymers such as hydroxypropyl methylcellulose and ethylcellulose and/or methacrylic acid polymers Eudragit RSPM and Carbopol 934P. The floating property was achieved using an effervescent mixture of sodium bicarbonate and anhydrous citric acid (1:1 mol/mol). Hardness, friability, content uniformity, and dissolution rate of the prepared floating tablets were evaluated. The formulation F10 composed of 28.5% Eudragit RSPM, 3% NaHCO3, and 7% citric acid provided sustained drug release. Results: In vitro results showed sustained release of F10 where the drug release percentage was 96.51%±1.75% after 24 hours (P=0.031).The pharmacokinetic results indicated that the area under the curve (AUC0–∞) of the prepared sustained-release floating tablets at infinity achieved 93.69 µg·h/mL compared to 49.89 µg·h/mL for the reference formulation (Ganaton®) and the relative bioavailability of the sustained-release formulation F10 increased to 187.80% (P=0.022). Conclusion: The prepared floating tablets of ITO HCl (F10) could be a promising drug delivery system with sustained-release action and enhanced drug bioavailability. Keywords: itopride HCl, oral drug delivery, stability study, bioavailabilityhttps://www.dovepress.com/design-and-in-vitroin-vivo-evaluation-of-sustained-release-floating-ta-peer-reviewed-article-DDDTItopride HCloral drug deliverystability studybioavailability. |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Ahmed SM Ahmed Ali A Ali AMA Hassan OA |
spellingShingle |
Ahmed SM Ahmed Ali A Ali AMA Hassan OA Design and in vitro/in vivo evaluation of sustained-release floating tablets of itopride hydrochloride Drug Design, Development and Therapy Itopride HCl oral drug delivery stability study bioavailability. |
author_facet |
Ahmed SM Ahmed Ali A Ali AMA Hassan OA |
author_sort |
Ahmed SM |
title |
Design and in vitro/in vivo evaluation of sustained-release floating tablets of itopride hydrochloride |
title_short |
Design and in vitro/in vivo evaluation of sustained-release floating tablets of itopride hydrochloride |
title_full |
Design and in vitro/in vivo evaluation of sustained-release floating tablets of itopride hydrochloride |
title_fullStr |
Design and in vitro/in vivo evaluation of sustained-release floating tablets of itopride hydrochloride |
title_full_unstemmed |
Design and in vitro/in vivo evaluation of sustained-release floating tablets of itopride hydrochloride |
title_sort |
design and in vitro/in vivo evaluation of sustained-release floating tablets of itopride hydrochloride |
publisher |
Dove Medical Press |
series |
Drug Design, Development and Therapy |
issn |
1177-8881 |
publishDate |
2016-12-01 |
description |
Sayed M Ahmed,1 Adel Ahmed Ali,2 Ahmed MA Ali,2,3 Omiya A Hassan2,4 1Department of Industrial Pharmacy, Faculty of Pharmacy, Assiut University, Assiut, 2Department of Pharmaceutics, Faculty of Pharmacy, Beni-Suef University, Beni-Suef, Egypt; 3Department of Pharmaceutics, Faculty of Pharmacy, Taif University, Taif, Kingdom of Saudi Arabia; 4Department of Pharmaceutics, Faculty of Pharmacy, Deraya University, El-Minia Gadida, Egypt Purpose: The aim of the present study was to improve the bioavailability of itopride (ITO) and sustain its action by formulating as a floating dosage form. Materials and methods: Sustained-release floating tablets of ITO hydrochloride (HCl) were prepared by direct compression using different hydrocolloid polymers such as hydroxypropyl methylcellulose and ethylcellulose and/or methacrylic acid polymers Eudragit RSPM and Carbopol 934P. The floating property was achieved using an effervescent mixture of sodium bicarbonate and anhydrous citric acid (1:1 mol/mol). Hardness, friability, content uniformity, and dissolution rate of the prepared floating tablets were evaluated. The formulation F10 composed of 28.5% Eudragit RSPM, 3% NaHCO3, and 7% citric acid provided sustained drug release. Results: In vitro results showed sustained release of F10 where the drug release percentage was 96.51%±1.75% after 24 hours (P=0.031).The pharmacokinetic results indicated that the area under the curve (AUC0–∞) of the prepared sustained-release floating tablets at infinity achieved 93.69 µg·h/mL compared to 49.89 µg·h/mL for the reference formulation (Ganaton®) and the relative bioavailability of the sustained-release formulation F10 increased to 187.80% (P=0.022). Conclusion: The prepared floating tablets of ITO HCl (F10) could be a promising drug delivery system with sustained-release action and enhanced drug bioavailability. Keywords: itopride HCl, oral drug delivery, stability study, bioavailability |
topic |
Itopride HCl oral drug delivery stability study bioavailability. |
url |
https://www.dovepress.com/design-and-in-vitroin-vivo-evaluation-of-sustained-release-floating-ta-peer-reviewed-article-DDDT |
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