Cortical abnormalities in youth at clinical high-risk for psychosis: Findings from the NAPLS2 cohort
In a recent machine learning study classifying “brain age” based on cross-sectional neuroanatomical data, clinical high-risk (CHR) individuals were observed to show deviation from the normal neuromaturational pattern, which in turn was predictive of greater risk of conversion to psychosis and a patt...
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Format: | Article |
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Elsevier
2019-01-01
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Series: | NeuroImage: Clinical |
Online Access: | http://www.sciencedirect.com/science/article/pii/S2213158219302128 |
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doaj-0315b5f169a14fdb95d8174624eeee19 |
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record_format |
Article |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Yoonho Chung Dana Allswede Jean Addington Carrie E. Bearden Kristin Cadenhead Barbara Cornblatt Daniel H. Mathalon Thomas McGlashan Diana Perkins Larry J. Seidman Ming Tsuang Elaine Walker Scott W. Woods Sarah McEwen Theo G.M. van Erp Tyrone D. Cannon |
spellingShingle |
Yoonho Chung Dana Allswede Jean Addington Carrie E. Bearden Kristin Cadenhead Barbara Cornblatt Daniel H. Mathalon Thomas McGlashan Diana Perkins Larry J. Seidman Ming Tsuang Elaine Walker Scott W. Woods Sarah McEwen Theo G.M. van Erp Tyrone D. Cannon Cortical abnormalities in youth at clinical high-risk for psychosis: Findings from the NAPLS2 cohort NeuroImage: Clinical |
author_facet |
Yoonho Chung Dana Allswede Jean Addington Carrie E. Bearden Kristin Cadenhead Barbara Cornblatt Daniel H. Mathalon Thomas McGlashan Diana Perkins Larry J. Seidman Ming Tsuang Elaine Walker Scott W. Woods Sarah McEwen Theo G.M. van Erp Tyrone D. Cannon |
author_sort |
Yoonho Chung |
title |
Cortical abnormalities in youth at clinical high-risk for psychosis: Findings from the NAPLS2 cohort |
title_short |
Cortical abnormalities in youth at clinical high-risk for psychosis: Findings from the NAPLS2 cohort |
title_full |
Cortical abnormalities in youth at clinical high-risk for psychosis: Findings from the NAPLS2 cohort |
title_fullStr |
Cortical abnormalities in youth at clinical high-risk for psychosis: Findings from the NAPLS2 cohort |
title_full_unstemmed |
Cortical abnormalities in youth at clinical high-risk for psychosis: Findings from the NAPLS2 cohort |
title_sort |
cortical abnormalities in youth at clinical high-risk for psychosis: findings from the napls2 cohort |
publisher |
Elsevier |
series |
NeuroImage: Clinical |
issn |
2213-1582 |
publishDate |
2019-01-01 |
description |
In a recent machine learning study classifying “brain age” based on cross-sectional neuroanatomical data, clinical high-risk (CHR) individuals were observed to show deviation from the normal neuromaturational pattern, which in turn was predictive of greater risk of conversion to psychosis and a pattern of stably poor functional outcome. These effects were unique to cases who were between 12 and 17 years of age when their prodromal and psychotic symptoms began, suggesting that neuroanatomical deviance observable at the point of ascertainment of a CHR syndrome marks risk for an early onset form of psychosis. In the present study, we sought to clarify the pattern of neuroanatomical deviance linked to this “early onset” form of psychosis and whether this deviance is associated with poorer premorbid functioning. T1 MRI scans from 378 CHR individuals and 190 healthy controls (HC) from the North American Prodrome Longitudinal Study (NAPLS2) were analyzed. Widespread smaller cortical volume was observed among CHR individuals compared with HC at baseline evaluation, particularly among the younger group (i.e., those who were 12 to 17 years of age). Moreover, the younger CHR individuals who converted or presented worsened clinical symptoms at follow-up (within 2 years) exhibited smaller surface area in rostral anterior cingulate, lateral and medial prefrontal regions, and parahippocampal gyrus relative to the younger CHR individuals who remitted or presented a stable pattern of prodromal symptoms at follow-up. In turn, poorer premorbid functioning in childhood was associated with smaller surface area in medial orbitofrontal, lateral frontal, rostral anterior cingulate, precuneus, and temporal regions. Together with our prior report, these results are consistent with the view that neuroanatomical deviance manifesting in early adolescence marks vulnerability to a form of psychosis presenting with poor premorbid adjustment, an earlier age of onset (generally prior to the age of 18 years), and poor long-term outcome. Keywords: Magnetic resonance imaging, Clinical high risk, Psychosis, Brain development, Premorbid functioning, Schizophrenia |
url |
http://www.sciencedirect.com/science/article/pii/S2213158219302128 |
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doaj-0315b5f169a14fdb95d8174624eeee192020-11-25T01:25:04ZengElsevierNeuroImage: Clinical2213-15822019-01-0123Cortical abnormalities in youth at clinical high-risk for psychosis: Findings from the NAPLS2 cohortYoonho Chung0Dana Allswede1Jean Addington2Carrie E. Bearden3Kristin Cadenhead4Barbara Cornblatt5Daniel H. Mathalon6Thomas McGlashan7Diana Perkins8Larry J. Seidman9Ming Tsuang10Elaine Walker11Scott W. Woods12Sarah McEwen13Theo G.M. van Erp14Tyrone D. Cannon15Department of Psychology, Yale University, 2 Hillhouse Ave., New Haven, CT 06520-8205, United StatesDepartment of Psychology, Yale University, 2 Hillhouse Ave., New Haven, CT 06520-8205, United StatesHotchkiss Brain Institute, Department of Psychiatry, University of Calgary, 3280 Hospital Drive NW, Calgary, AB, T2N4Z6, CanadaSemel Institute for Neuroscience and Human Behavior and Department of Psychology, UCLA, 760 Westwood Plaza, Los Angeles, CA, 90095, United StatesDepartment of Psychiatry, UCSD, 9500 Gilman Drive, La Jolla, CA 92093-0761, United StatesDepartment of Psychiatry, Zucker Hillside Hospital, 75-59 263rd St., Queens, NY 11004, United StatesDepartment of Psychiatry, UCSF, 401 Parnassus Avenue, San Francisco, CA 94143, United StatesDepartment of Psychiatry, Yale University, 300 George St., New Haven, CT 06511, United StatesDepartment of Psychiatry, University of North Carolina, 101 Manning Dr, Chapel Hill, NC 27514, United States; Renaissance Computing Institute, University of North Carolina, Chapel Hill, United StatesDepartment of Psychiatry, Beth Israel Deaconess Medical Center and Harvard Medical School, 401 Park Drive, 2 East, Boston, MA 02215, United States; Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, 401 Park Drive, 2 West, Boston, MA 02215, United StatesDepartment of Psychiatry, UCSD, 9500 Gilman Drive, La Jolla, CA 92093-0761, United StatesDepartment of Psychology, Emory University, 487 Psychology Building, 36 Eagle Row, Atlanta, GA 30322, United StatesDepartment of Psychiatry, Yale University, 300 George St., New Haven, CT 06511, United StatesDepartment of Psychiatry, UCSD, 9500 Gilman Drive, La Jolla, CA 92093-0761, United StatesClinical Translational Neuroscience Laboratory, Department of Psychiatry and Human Behavior, UC Irvine, 5251 California Ave, Irvine, CA, 92617, United StatesDepartment of Psychology, Yale University, 2 Hillhouse Ave., New Haven, CT 06520-8205, United States; Department of Psychiatry, Yale University, 300 George St., New Haven, CT 06511, United States; Corresponding author at: Department of Psychology, 2 Hillhouse Avenue, New Haven, CT 06511, United States.In a recent machine learning study classifying “brain age” based on cross-sectional neuroanatomical data, clinical high-risk (CHR) individuals were observed to show deviation from the normal neuromaturational pattern, which in turn was predictive of greater risk of conversion to psychosis and a pattern of stably poor functional outcome. These effects were unique to cases who were between 12 and 17 years of age when their prodromal and psychotic symptoms began, suggesting that neuroanatomical deviance observable at the point of ascertainment of a CHR syndrome marks risk for an early onset form of psychosis. In the present study, we sought to clarify the pattern of neuroanatomical deviance linked to this “early onset” form of psychosis and whether this deviance is associated with poorer premorbid functioning. T1 MRI scans from 378 CHR individuals and 190 healthy controls (HC) from the North American Prodrome Longitudinal Study (NAPLS2) were analyzed. Widespread smaller cortical volume was observed among CHR individuals compared with HC at baseline evaluation, particularly among the younger group (i.e., those who were 12 to 17 years of age). Moreover, the younger CHR individuals who converted or presented worsened clinical symptoms at follow-up (within 2 years) exhibited smaller surface area in rostral anterior cingulate, lateral and medial prefrontal regions, and parahippocampal gyrus relative to the younger CHR individuals who remitted or presented a stable pattern of prodromal symptoms at follow-up. In turn, poorer premorbid functioning in childhood was associated with smaller surface area in medial orbitofrontal, lateral frontal, rostral anterior cingulate, precuneus, and temporal regions. Together with our prior report, these results are consistent with the view that neuroanatomical deviance manifesting in early adolescence marks vulnerability to a form of psychosis presenting with poor premorbid adjustment, an earlier age of onset (generally prior to the age of 18 years), and poor long-term outcome. Keywords: Magnetic resonance imaging, Clinical high risk, Psychosis, Brain development, Premorbid functioning, Schizophreniahttp://www.sciencedirect.com/science/article/pii/S2213158219302128 |