Comprehensive Profile of Acute Mitochondrial Dysfunction in a Preclinical Model of Severe Penetrating TBI

Comprehensive Profile of Acute Mitochondrial Dysfunction in a Preclinical Model of Severe Penetrating TBI

Mitochondria constitute a central role in brain energy metabolism, and play a pivotal role in the development of secondary pathophysiology and subsequent neuronal cell death following traumatic brain injury (TBI). Under normal circumstances, the brain consumes glucose as the preferred energy source...

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Bibliographic Details
Main Authors: Jignesh D. Pandya, Lai Yee Leung, Xiaofang Yang, William J. Flerlage, Janice S. Gilsdorf, Ying Deng-Bryant, Deborah A. Shear
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-06-01
Series:Frontiers in Neurology
Subjects:
traumatic brain injury (TBI)
penetrating ballistic-like brain injury (PBBI)
alternative biofuels
brain energy metabolism
energy crisis
mitochondria preferred substrates
Online Access:https://www.frontiersin.org/article/10.3389/fneur.2019.00605/full

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