Development of bioactive and biocompatible ceramic composites based on potassium polytitanate
Bioactive and biocompatible composites were successfully prepared by reactive sintering of mixtures of a crystalline titanate precursor and 45S5 Bioglass®. The polytitanate/glass precursor ratios were 20/80, 40/60, 60/40 or 80/20 (wt.%). The powder mixtures were uniaxially pressed and heat treated a...
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University of Novi Sad
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doaj-033af82357c5493f8e5fe57901d732462020-11-25T02:31:26ZengUniversity of Novi SadProcessing and Application of Ceramics1820-61312406-10342019-06-0113214915610.2298/PAC1902149VDevelopment of bioactive and biocompatible ceramic composites based on potassium polytitanateÁngel Villalpando-Reyna0Dora A. Cortés-Hernández1Jose M. Granjeiro2Marcelo Prado3Alexander V. Gorokhovsky4José C. Escobedo-Bocardo5José M. Almanza-Robles6David Rentería-Zamarrón7CINVESTAV-Unidad Saltillo, Carretera Saltillo - Monterrey km 13, Apdo. Postal 663, C.P. 25000, Saltillo, Coahuila, MéxicoCINVESTAV-Unidad Saltillo, Carretera Saltillo - Monterrey km 13, Apdo. Postal 663, C.P. 25000, Saltillo, Coahuila, MéxicoUFF, Universidade Federal Fluminense, Outeiro do São Joao Batista s/n Campus do Valonginho, Centro/Niterói, BrazilIME, Instituto Militar de Engenharia, Praça Gen. Tibúrcio, № 80 Urca, Rio de Janeiro - RJ, BrazilSaratov State Technical University, Saratov, RussiaCINVESTAV-Unidad Saltillo, Carretera Saltillo - Monterrey km 13, Apdo. Postal 663, C.P. 25000, Saltillo, Coahuila, MéxicoCINVESTAV-Unidad Saltillo, Carretera Saltillo - Monterrey km 13, Apdo. Postal 663, C.P. 25000, Saltillo, Coahuila, MéxicoDivisión de Estudios de Posgrado e Investigación. Tecnológico Nacional de México, Instituto Tecnológico de Saltillo, Saltillo, Coahuila, MéxicoBioactive and biocompatible composites were successfully prepared by reactive sintering of mixtures of a crystalline titanate precursor and 45S5 Bioglass®. The polytitanate/glass precursor ratios were 20/80, 40/60, 60/40 or 80/20 (wt.%). The powder mixtures were uniaxially pressed and heat treated at 1000 °C for 1 h. During sintering, intensive interactions between raw materials occurred. The formed main crystalline phases were: potassium hexatitanate (K2Ti6O13), calcium titanate (CaTiO3), calcium silicate (CaSiO4) and sodium-calcium silicate (Na6Ca3Si6O18). Additionally, a Si-rich glassy phase was also observed. The mechanism of apatite formation indicated that both crystalline and amorphous phases play important roles in this process. A homogeneous apatite layer was formed on Si–OH, Ti–H-rich interfaces. In vitro bioactivity was assessed using simulated body fluid (SBF K-9). The in vitro cytotoxicity behaviour was evaluated using a human osteoblastlike cells model and compressive strength by ASTM C-773 standard. All the composites demonstrated high bioactivity as cytotoxicity assays indicated a biocompatibility similar to that of the negative control. The samples showed high cell adherence and elongation cell characteristics similar to those observed on biocompatible systems. The compressive strength of the sintered samples decreased as the polytitanate content precursor was increased. The results obtained indicate that these materials are highly promising composites for medical applications.http://www.tf.uns.ac.rs/publikacije/PAC/pdf/PAC%2044%2005.pdfsilicate glassespotassium titanateapatite formationcytotoxicitycell adhesion |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Ángel Villalpando-Reyna Dora A. Cortés-Hernández Jose M. Granjeiro Marcelo Prado Alexander V. Gorokhovsky José C. Escobedo-Bocardo José M. Almanza-Robles David Rentería-Zamarrón |
spellingShingle |
Ángel Villalpando-Reyna Dora A. Cortés-Hernández Jose M. Granjeiro Marcelo Prado Alexander V. Gorokhovsky José C. Escobedo-Bocardo José M. Almanza-Robles David Rentería-Zamarrón Development of bioactive and biocompatible ceramic composites based on potassium polytitanate Processing and Application of Ceramics silicate glasses potassium titanate apatite formation cytotoxicity cell adhesion |
author_facet |
Ángel Villalpando-Reyna Dora A. Cortés-Hernández Jose M. Granjeiro Marcelo Prado Alexander V. Gorokhovsky José C. Escobedo-Bocardo José M. Almanza-Robles David Rentería-Zamarrón |
author_sort |
Ángel Villalpando-Reyna |
title |
Development of bioactive and biocompatible ceramic composites based on potassium polytitanate |
title_short |
Development of bioactive and biocompatible ceramic composites based on potassium polytitanate |
title_full |
Development of bioactive and biocompatible ceramic composites based on potassium polytitanate |
title_fullStr |
Development of bioactive and biocompatible ceramic composites based on potassium polytitanate |
title_full_unstemmed |
Development of bioactive and biocompatible ceramic composites based on potassium polytitanate |
title_sort |
development of bioactive and biocompatible ceramic composites based on potassium polytitanate |
publisher |
University of Novi Sad |
series |
Processing and Application of Ceramics |
issn |
1820-6131 2406-1034 |
publishDate |
2019-06-01 |
description |
Bioactive and biocompatible composites were successfully prepared by reactive sintering of mixtures of a crystalline titanate precursor and 45S5 Bioglass®. The polytitanate/glass precursor ratios were 20/80, 40/60, 60/40 or 80/20 (wt.%). The powder mixtures were uniaxially pressed and heat treated at 1000 °C for 1 h. During sintering, intensive interactions between raw materials occurred. The formed main crystalline phases were: potassium hexatitanate (K2Ti6O13), calcium titanate (CaTiO3), calcium silicate (CaSiO4) and sodium-calcium silicate (Na6Ca3Si6O18). Additionally, a Si-rich glassy phase was also observed. The mechanism of apatite formation indicated that both crystalline and amorphous phases play important roles in this process. A homogeneous apatite layer was formed on Si–OH, Ti–H-rich interfaces. In vitro bioactivity was assessed using simulated body fluid (SBF K-9). The in vitro cytotoxicity behaviour was evaluated using a human osteoblastlike cells model and compressive strength by ASTM C-773 standard. All the composites demonstrated high bioactivity as cytotoxicity assays indicated a biocompatibility similar to that of the negative control. The samples showed high cell adherence and elongation cell characteristics similar to those observed on biocompatible systems. The compressive strength of the sintered samples decreased as the polytitanate content precursor was increased. The results obtained indicate that these materials are highly promising composites for medical applications. |
topic |
silicate glasses potassium titanate apatite formation cytotoxicity cell adhesion |
url |
http://www.tf.uns.ac.rs/publikacije/PAC/pdf/PAC%2044%2005.pdf |
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