Novel quinazolinone MJ-29 triggers endoplasmic reticulum stress and intrinsic apoptosis in murine leukemia WEHI-3 cells and inhibits leukemic mice.

Novel quinazolinone MJ-29 triggers endoplasmic reticulum stress and intrinsic apoptosis in murine leukemia WEHI-3 cells and inhibits leukemic mice.

The present study was to explore the biological responses of the newly compound, MJ-29 in murine myelomonocytic leukemia WEHI-3 cells in vitro and in vivo fates. We focused on the in vitro effects of MJ-29 on ER stress and mitochondria-dependent apoptotic death in WEHI-3 cells, and to hypothesize th...

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Bibliographic Details
Main Authors: Chi-Cheng Lu, Jai-Sing Yang, Jo-Hua Chiang, Mann-Jen Hour, Kuei-Li Lin, Jen-Jyh Lin, Wen-Wen Huang, Minoru Tsuzuki, Tsung-Han Lee, Jing-Gung Chung
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3360742?pdf=render

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