Inhibition of Tyrosine-Phosphorylated STAT3 in Human Breast and Lung Cancer Cells by Manuka Honey is Mediated by Selective Antagonism of the IL-6 Receptor

Inhibition of Tyrosine-Phosphorylated STAT3 in Human Breast and Lung Cancer Cells by Manuka Honey is Mediated by Selective Antagonism of the IL-6 Receptor

Aberrantly high levels of tyrosine-phosphorylated signal transducer and activator of transcription 3 (p-STAT3) are found constitutively in ~50% of human lung and breast cancers, acting as an oncogenic transcription factor. We previously demonstrated that Manuka honey (MH) inhibits p-STAT3 in breast...

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Bibliographic Details
Main Authors: Priyanka Aryappalli, Khadija Shabbiri, Razan J. Masad, Roadha H. Al-Marri, Shoja M. Haneefa, Yassir A. Mohamed, Kholoud Arafat, Samir Attoub, Otavio Cabral-Marques, Khalil B. Ramadi, Maria J. Fernandez-Cabezudo, Basel K. al-Ramadi
Format: Article
Language:English
Published: MDPI AG 2019-09-01
Series:International Journal of Molecular Sciences
Subjects:
Manuka honey
Flavonoids
IL-6 receptor
STAT3
IL-6
breast and lung cancers
Online Access:https://www.mdpi.com/1422-0067/20/18/4340

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