Fibrinogen Is A Coagulation Marker Associated With The Prognosis Of Endometrial Cancer

• Main Authors: Li Q, Cong R, Kong F, Ma J, Wu Q, Ma X
• Format: Article
• Language: English
• Published: Dove Medical Press 2019-11-01
• Series: OncoTargets and Therapy
• Subjects: endometrial carcinoma; hemostatic markers; clinicopathological characteristics; survival
• Online Access: https://www.dovepress.com/fibrinogen-is-a-coagulation-marker-associated-with-the-prognosis-of-en-peer-reviewed-article-OTT

Qing Li,1 Rong Cong,1 Fanfei Kong,1 Jian Ma,1 Qijun Wu,2 Xiaoxin Ma1 1Department of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, Shenyang, Liaoning, People’s Republic of China; 2Department of Clinical Epidemiology, Shengjing Hospital of China Medical University, Shenyang, Liaoning, People’s Republic of ChinaCorrespondence: Xiaoxin MaDepartment of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, No.36, SanHao Street, Shenyang, Liaoning 110004, People’s Republic of ChinaTel [phone]Email [e-mail]: The present study aimed to identify coagulation markers with prognostic value in the setting of surgically treated endometrial cancer.Patients and methods: A total of 942 patients with endometrial cancer who underwent surgery were included in the study. The preoperative prothrombin time (PT), activated partial thromboplastin time (aPTT), thrombin time (TT), prothrombin time activity (PTA), fibrinogen and D-dimer values were analyzed to determine their potential associations with clinicopathological characteristics. Survival analysis was performed using the Kaplan-Meier method, p-values were calculated using the log-rank text, and the prognostic factors were evaluated using Cox’s proportional hazards regression model.Results: The preoperative plasma fibrinogen and D-dimer concentrations were significantly different among patients with different ages, pre/post-menopausal status, International Federation of Obstetrics and Gynecology Association (FIGO) stage, tumor grade, depth of myometrial invasion, histological type and lymphatic vessel space invasion. Fibrinogen level was also asscoiated with body mass index (BMI) and comorbidities, and D-dimer level was asscoiated with preoperative radiotherapy and chemotherapy. APTT was different in patients in pre/post-menopausal status and with or without comorbidities. PTA was asscoiated with BMI and lymphovascular invasion. TT was different between different age groups, different menopause status groups, as well as different FIGO stage groups. A multivariate analysis identified high fibrinogen levels (>3.25 g/L) as an independent prognostic factor for overall survival (HR=1.807; 95% CI=1.003–3.253; p=0.049).Conclusion: High pretreatment fibrinogen levels are associated with poor overall survival and represent a valuable independent prognostic factor in patients with endometrial cancer. PT, aPTT, TT, PTA and D-dimer levels cannot be used as independent prognostic factors for endometrial cancer.Keywords: endometrial carcinoma, hemostatic markers, clinicopathological characteristics, survival