DDGun: an untrained method for the prediction of protein stability changes upon single and multiple point variations

DDGun: an untrained method for the prediction of protein stability changes upon single and multiple point variations

Abstract Background Predicting the effect of single point variations on protein stability constitutes a crucial step toward understanding the relationship between protein structure and function. To this end, several methods have been developed to predict changes in the Gibbs free energy of unfolding...

Full description

Bibliographic Details
Main Authors: Ludovica Montanucci, Emidio Capriotti, Yotam Frank, Nir Ben-Tal, Piero Fariselli
Format: Article
Language:English
Published: BMC 2019-07-01
Series:BMC Bioinformatics
Subjects:
Unfolding free energy change
Multiple site variation
Protein stability
Protein variant
Online Access:http://link.springer.com/article/10.1186/s12859-019-2923-1

Internet

http://link.springer.com/article/10.1186/s12859-019-2923-1

Similar Items