Harmine, a dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) inhibitor induces caspase-mediated apoptosis in neuroblastoma

Harmine, a dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) inhibitor induces caspase-mediated apoptosis in neuroblastoma

Abstract Background Neuroblastoma (NB) is an early childhood malignancy that arises from the developing sympathetic nervous system. Harmine is a tricyclic β-carboline alkaloid isolated from the harmal plant that exhibits both cytostatic and cytotoxic effects. Harmine is capable of blocking the activ...

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Bibliographic Details
Main Authors: Katie L. Uhl, Chad R. Schultz, Dirk Geerts, André S. Bachmann
Format: Article
Language:English
Published: BMC 2018-06-01
Series:Cancer Cell International
Subjects:
Apoptosis
DYRK2
Harmine
Molecular docking
Natural products
Neuroblastoma
Online Access:http://link.springer.com/article/10.1186/s12935-018-0574-3

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