Clinical features and diagnosis of Ph - negative myeloproliferative neoplasms occurring in conjunction with the antiphospholipid syndrome

• Main Authors: A L Melikyan, I N Subortseva, E A Koloshejnova, E A Gilyazitdinova, K S Shashkina, L A Gorgidze, Zh V Tratsevskaya, O V Margolin
• Format: Article
• Language: Russian
• Published: "Consilium Medicum" Publishing house 2019-07-01
• Series: Терапевтический архив
• Subjects: myeloproliferative neoplasms; antiphospholipid syndrome; thrombosis
• Online Access: https://ter-arkhiv.ru/0040-3660/article/view/33631
• ISSN: 0040-3660; 2309-5342

Thrombosis is a serious and extremely dangerous disease that has a negative impact on the quality and longevity. Antiphospholipid syndrome (APS) is a pathology characterized by recurring venous, arterial, microvasculature thrombosis, pregnancy pathology with loss of the fetus and the synthesis of antiphospholipid antibodies. A high risk of thrombotic complications is also observed in patients with myeloproliferative neoplasms (MPN). This article presents a description of three clinical cases of Ph - negative myeloproliferative diseases, occurring in conjunction with APS. In all cases, recurrent thrombosis allowed to suspect the presence of two diseases - MPN and APS.