Cholesterolosis and chronic cholecystitis: comperative analysis of state of gall-bladder wall.

• Main Authors: Shcherbinina M.B., Zakrevskaya Y.V., Korolenko A.S., Lymar L.I.
• Format: Article
• Language: Russian
• Published: Ministry of Health of Ukraine. Dnipropetrovsk Medical Academy 2007-01-01
• Series: Морфологія
• Subjects: cholesterolosis; chronic cholecystitis; xantom cells; cellular contain of mucosa
• Online Access: http://www.morphology.dp.ua/_pub/MORPHO-2007-01-03/07cmbszp.pdf

The mechanisms of lipid infiltration of gall-bladder (GB) wall in case of cholesterolosis are not known now. The aim of this work was studying the morphologic peculiarities of forming cholesterolosis comparing with state of chronic cholecystitis by anatomical parts of GB using system stereometric analysis. There was performed the histological examination of 2 groups of GB removed by standart laparoscopic cholecystectomy due to cholecystolithiasis. The first group contains GB with diffuse reticular form of cholesterolosis (n=28), the second group contains GB with chronic inflammation without signs of activation (n=21). Using G.G.Avtandilov’s recommendations there were determined the volume interrelations of stroma and epithelium (stromal-epithelial index), cellular content of lamina propria of GB mucosa (neutrophyles, eosinophyles, lymphocytes, plasmocytes, xantom cells), lymphocytes-plasmocytes index. The results were evaluated by t-criterion of Student, changes were statistically evident if р<0,05. There was also used the correlative analysis with estimation of correlation coefficient t. There was established that in case of GB cholesterlolsis the morphologic changes in GB wall had dystrophic character and might accompany with not marked sclerotic changes in mucosa. In case of chronic cholecystitis the inflammatory process lead to atrophic-sclerotic changes. In case of cholecystolithiasis with diffuse reticular form of GB cholesterolosis or chronic cholecystitis the prevalent localization of pathology is corpus and fundus of organ.