Novel Immune Microlens Imaging for Detection of Antigen and Antibody
Detection and analysis of antigen-antibody reaction is one of the most critical detection techniques in the fields of medicine, biology, environmental science, and food safety. Traditional and classical methods for detecting antigen and antibody encounter many problems, such as time-consuming, high...
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Series: | Journal of Immunology Research |
Online Access: | http://dx.doi.org/10.1155/2019/5474519 |
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doaj-035f232721eb4cac83745ff0a009f4d92020-11-25T02:34:03ZengHindawi LimitedJournal of Immunology Research2314-88612314-71562019-01-01201910.1155/2019/54745195474519Novel Immune Microlens Imaging for Detection of Antigen and AntibodyJiahui Liang0Xiaotian Ye1Jiang He2Jing Liu3Yaoxiong Huang4Feiyue Xing5Institute of Tissue Transplantation and Immunology, Department of Immunobiology, Jinan University, Guangzhou 510632, ChinaInstitute of Tissue Transplantation and Immunology, Department of Immunobiology, Jinan University, Guangzhou 510632, ChinaDepartment of Biomedical Engineering, Jinan University, Guangzhou 510632, ChinaSchool of Stomatology, Jinan University, Guangzhou 510632, ChinaDepartment of Biomedical Engineering, Jinan University, Guangzhou 510632, ChinaInstitute of Tissue Transplantation and Immunology, Department of Immunobiology, Jinan University, Guangzhou 510632, ChinaDetection and analysis of antigen-antibody reaction is one of the most critical detection techniques in the fields of medicine, biology, environmental science, and food safety. Traditional and classical methods for detecting antigen and antibody encounter many problems, such as time-consuming, high cost, and low accuracy. A novel immune microsphere imaging technique by the microlens is used to test the changes of refractive index before and after antigen-antibody reaction. It can quickly perform qualitative and quantitative determination for antigen-antibody reaction without any labeling, premodification, postwashing, and expensive enzymes. Here, we feature and discuss its principle and advantages, structure of a microlens immunoassay instrument, and potential in measuring clinical samples. It is promising to be developed for application to diagnosis of clinical diseases.http://dx.doi.org/10.1155/2019/5474519 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Jiahui Liang Xiaotian Ye Jiang He Jing Liu Yaoxiong Huang Feiyue Xing |
spellingShingle |
Jiahui Liang Xiaotian Ye Jiang He Jing Liu Yaoxiong Huang Feiyue Xing Novel Immune Microlens Imaging for Detection of Antigen and Antibody Journal of Immunology Research |
author_facet |
Jiahui Liang Xiaotian Ye Jiang He Jing Liu Yaoxiong Huang Feiyue Xing |
author_sort |
Jiahui Liang |
title |
Novel Immune Microlens Imaging for Detection of Antigen and Antibody |
title_short |
Novel Immune Microlens Imaging for Detection of Antigen and Antibody |
title_full |
Novel Immune Microlens Imaging for Detection of Antigen and Antibody |
title_fullStr |
Novel Immune Microlens Imaging for Detection of Antigen and Antibody |
title_full_unstemmed |
Novel Immune Microlens Imaging for Detection of Antigen and Antibody |
title_sort |
novel immune microlens imaging for detection of antigen and antibody |
publisher |
Hindawi Limited |
series |
Journal of Immunology Research |
issn |
2314-8861 2314-7156 |
publishDate |
2019-01-01 |
description |
Detection and analysis of antigen-antibody reaction is one of the most critical detection techniques in the fields of medicine, biology, environmental science, and food safety. Traditional and classical methods for detecting antigen and antibody encounter many problems, such as time-consuming, high cost, and low accuracy. A novel immune microsphere imaging technique by the microlens is used to test the changes of refractive index before and after antigen-antibody reaction. It can quickly perform qualitative and quantitative determination for antigen-antibody reaction without any labeling, premodification, postwashing, and expensive enzymes. Here, we feature and discuss its principle and advantages, structure of a microlens immunoassay instrument, and potential in measuring clinical samples. It is promising to be developed for application to diagnosis of clinical diseases. |
url |
http://dx.doi.org/10.1155/2019/5474519 |
work_keys_str_mv |
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