Somatic mutagenesis in satellite cells associates with human skeletal muscle aging
Aging skeletal muscle shows declining numbers and activity of satellite cells. Here, Franco et al. show that in satellite cells of the human leg muscle vastus lateralis, somatic mutations accumulate with age and that these mutations become enriched in exons and promoters of genes involved in muscle...
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Bibliographic Details
Main Authors: |
Irene Franco,
Anna Johansson,
Karl Olsson,
Peter Vrtačnik,
Pär Lundin,
Hafdis T. Helgadottir,
Malin Larsson,
Gwladys Revêchon,
Carla Bosia,
Andrea Pagnani,
Paolo Provero,
Thomas Gustafsson,
Helene Fischer,
Maria Eriksson |
Format: | Article
|
Language: | English |
Published: |
Nature Publishing Group
2018-02-01
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Series: | Nature Communications
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Online Access: | https://doi.org/10.1038/s41467-018-03244-6
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