Somatic mutagenesis in satellite cells associates with human skeletal muscle aging
Aging skeletal muscle shows declining numbers and activity of satellite cells. Here, Franco et al. show that in satellite cells of the human leg muscle vastus lateralis, somatic mutations accumulate with age and that these mutations become enriched in exons and promoters of genes involved in muscle...
| Main Authors: | , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Publishing Group
2018-02-01
|
| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-018-03244-6 |
| id |
doaj-0363043147a94b90adfd4993239327c0 |
|---|---|
| record_format |
Article |
| spelling |
doaj-0363043147a94b90adfd4993239327c02021-05-11T09:24:13ZengNature Publishing GroupNature Communications2041-17232018-02-019111210.1038/s41467-018-03244-6Somatic mutagenesis in satellite cells associates with human skeletal muscle agingIrene Franco0Anna Johansson1Karl Olsson2Peter Vrtačnik3Pär Lundin4Hafdis T. Helgadottir5Malin Larsson6Gwladys Revêchon7Carla Bosia8Andrea Pagnani9Paolo Provero10Thomas Gustafsson11Helene Fischer12Maria Eriksson13Department of Biosciences and Nutrition, Center for Innovative Medicine, Karolinska InstitutetScience for Life Laboratory, Department of Cell and Molecular Biology, Uppsala UniversityDivision of Clinical Physiology, Department of Laboratory Medicine, Karolinska InstitutetDepartment of Biosciences and Nutrition, Center for Innovative Medicine, Karolinska InstitutetDepartment of Biosciences and Nutrition, Center for Innovative Medicine, Karolinska InstitutetDepartment of Biosciences and Nutrition, Center for Innovative Medicine, Karolinska InstitutetScience for Life Laboratory, Department of Physics, Chemistry and Biology, Linköping UniversityDepartment of Biosciences and Nutrition, Center for Innovative Medicine, Karolinska InstitutetItalian Institute for Genomic Medicine (IIGM)Italian Institute for Genomic Medicine (IIGM)Department of Molecular Biotechnology and Health Sciences, Molecular Biotechnology CenterDivision of Clinical Physiology, Department of Laboratory Medicine, Karolinska InstitutetDivision of Clinical Physiology, Department of Laboratory Medicine, Karolinska InstitutetDepartment of Biosciences and Nutrition, Center for Innovative Medicine, Karolinska InstitutetAging skeletal muscle shows declining numbers and activity of satellite cells. Here, Franco et al. show that in satellite cells of the human leg muscle vastus lateralis, somatic mutations accumulate with age and that these mutations become enriched in exons and promoters of genes involved in muscle function.https://doi.org/10.1038/s41467-018-03244-6 |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Irene Franco Anna Johansson Karl Olsson Peter Vrtačnik Pär Lundin Hafdis T. Helgadottir Malin Larsson Gwladys Revêchon Carla Bosia Andrea Pagnani Paolo Provero Thomas Gustafsson Helene Fischer Maria Eriksson |
| spellingShingle |
Irene Franco Anna Johansson Karl Olsson Peter Vrtačnik Pär Lundin Hafdis T. Helgadottir Malin Larsson Gwladys Revêchon Carla Bosia Andrea Pagnani Paolo Provero Thomas Gustafsson Helene Fischer Maria Eriksson Somatic mutagenesis in satellite cells associates with human skeletal muscle aging Nature Communications |
| author_facet |
Irene Franco Anna Johansson Karl Olsson Peter Vrtačnik Pär Lundin Hafdis T. Helgadottir Malin Larsson Gwladys Revêchon Carla Bosia Andrea Pagnani Paolo Provero Thomas Gustafsson Helene Fischer Maria Eriksson |
| author_sort |
Irene Franco |
| title |
Somatic mutagenesis in satellite cells associates with human skeletal muscle aging |
| title_short |
Somatic mutagenesis in satellite cells associates with human skeletal muscle aging |
| title_full |
Somatic mutagenesis in satellite cells associates with human skeletal muscle aging |
| title_fullStr |
Somatic mutagenesis in satellite cells associates with human skeletal muscle aging |
| title_full_unstemmed |
Somatic mutagenesis in satellite cells associates with human skeletal muscle aging |
| title_sort |
somatic mutagenesis in satellite cells associates with human skeletal muscle aging |
| publisher |
Nature Publishing Group |
| series |
Nature Communications |
| issn |
2041-1723 |
| publishDate |
2018-02-01 |
| description |
Aging skeletal muscle shows declining numbers and activity of satellite cells. Here, Franco et al. show that in satellite cells of the human leg muscle vastus lateralis, somatic mutations accumulate with age and that these mutations become enriched in exons and promoters of genes involved in muscle function. |
| url |
https://doi.org/10.1038/s41467-018-03244-6 |
| work_keys_str_mv |
AT irenefranco somaticmutagenesisinsatellitecellsassociateswithhumanskeletalmuscleaging AT annajohansson somaticmutagenesisinsatellitecellsassociateswithhumanskeletalmuscleaging AT karlolsson somaticmutagenesisinsatellitecellsassociateswithhumanskeletalmuscleaging AT petervrtacnik somaticmutagenesisinsatellitecellsassociateswithhumanskeletalmuscleaging AT parlundin somaticmutagenesisinsatellitecellsassociateswithhumanskeletalmuscleaging AT hafdisthelgadottir somaticmutagenesisinsatellitecellsassociateswithhumanskeletalmuscleaging AT malinlarsson somaticmutagenesisinsatellitecellsassociateswithhumanskeletalmuscleaging AT gwladysrevechon somaticmutagenesisinsatellitecellsassociateswithhumanskeletalmuscleaging AT carlabosia somaticmutagenesisinsatellitecellsassociateswithhumanskeletalmuscleaging AT andreapagnani somaticmutagenesisinsatellitecellsassociateswithhumanskeletalmuscleaging AT paoloprovero somaticmutagenesisinsatellitecellsassociateswithhumanskeletalmuscleaging AT thomasgustafsson somaticmutagenesisinsatellitecellsassociateswithhumanskeletalmuscleaging AT helenefischer somaticmutagenesisinsatellitecellsassociateswithhumanskeletalmuscleaging AT mariaeriksson somaticmutagenesisinsatellitecellsassociateswithhumanskeletalmuscleaging |
| _version_ |
1721449836982566912 |