Inhibitors of Fatty Acid Synthesis Induce PPARα-Regulated Fatty Acid β-Oxidative Genes: Synergistic Roles of L-FABP and Glucose

Inhibitors of Fatty Acid Synthesis Induce PPARα-Regulated Fatty Acid β-Oxidative Genes: Synergistic Roles of L-FABP and Glucose

While TOFA (acetyl CoA carboxylase inhibitor) and C75 (fatty acid synthase inhibitor) prevent lipid accumulation by inhibiting fatty acid synthesis, the mechanism of action is not simply accounted for by inhibition of the enzymes alone. Liver fatty acid binding protein (L-FABP), a medi...

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Bibliographic Details
Main Authors: Huan Huang, Avery L. McIntosh, Gregory G. Martin, Anca D. Petrescu, Kerstin K. Landrock, Danilo Landrock, Ann B. Kier, Friedhelm Schroeder
Format: Article
Language:English
Published: Hindawi Limited 2013-01-01
Series:PPAR Research
Online Access:http://dx.doi.org/10.1155/2013/865604

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