The Role of Hemoglobin Oxidation Products in Triggering Inflammatory Response Upon Intraventricular Hemorrhage in Premature Infants

The Role of Hemoglobin Oxidation Products in Triggering Inflammatory Response Upon Intraventricular Hemorrhage in Premature Infants

Intraventricular hemorrhage (IVH) is a frequent complication of prematurity that is associated with high neonatal mortality and morbidity. IVH is accompanied by red blood cell (RBC) lysis, hemoglobin (Hb) oxidation, and sterile inflammation. Here we investigated whether extracellular Hb, metHb, ferr...

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Bibliographic Details
Main Authors: Judit Erdei, Andrea Tóth, Andrea Nagy, Benard Bogonko Nyakundi, Zsolt Fejes, Béla Nagy Jr., László Novák, László Bognár, Enikö Balogh, György Paragh, János Kappelmayer, Attila Bácsi, Viktória Jeney
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-03-01
Series:Frontiers in Immunology
Subjects:
intraventricular hemorrhage
hemoglobin
heme
premature infants
cerebrospinal fluid
adhesion molecules
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.00228/full

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