Epidemiology and management of chronic thromboembolic pulmonary hypertension: experience from two expert centers
Objectives: Chronic thromboembolic pulmonary hypertension (CTEPH) is a rare, distinct pulmonary vascular disease, and therefore, there is a lack of data regarding its clinical presentation, diagnosis, and management at a national basis. We aimed to describe the demographics and management of patient...
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doaj-038a279fea0d4a1297e374927485a17a2020-11-25T02:01:55ZengElsevierHellenic Journal of Cardiology1109-96662018-01-015911623Epidemiology and management of chronic thromboembolic pulmonary hypertension: experience from two expert centersMaria Anna Bazmpani0Alexandra Arvanitaki1Maria Toumpourleka2Georgia Pitsiou3Evangelia Panagiotidou4Sophia Anastasia Mouratoglou5Georgios Sianos6Stavros Hadjimiltiades7Antonios Pitsis8Eckhard Mayer9Ioannis Stanopoulos10Haralambos Karvounis11George Giannakoulas12First Cardiology Department, AHEPA University Hospital, Aristotle University of Thessaloniki, GreeceFirst Cardiology Department, AHEPA University Hospital, Aristotle University of Thessaloniki, GreeceFirst Cardiology Department, AHEPA University Hospital, Aristotle University of Thessaloniki, GreeceRespiratory Intensive Care Unit, Aristotle University of Thessaloniki, G.H. “G. Papanikolaou”, Exohi, Thessaloniki, GreeceRespiratory Intensive Care Unit, Aristotle University of Thessaloniki, G.H. “G. Papanikolaou”, Exohi, Thessaloniki, GreeceFirst Cardiology Department, AHEPA University Hospital, Aristotle University of Thessaloniki, GreeceFirst Cardiology Department, AHEPA University Hospital, Aristotle University of Thessaloniki, GreeceFirst Cardiology Department, AHEPA University Hospital, Aristotle University of Thessaloniki, GreeceAgios Lukas Hospital, Thessaloniki, GreeceKerckhoff Heart and Lung Center, Bad Nauheim, GermanyRespiratory Intensive Care Unit, Aristotle University of Thessaloniki, G.H. “G. Papanikolaou”, Exohi, Thessaloniki, GreeceFirst Cardiology Department, AHEPA University Hospital, Aristotle University of Thessaloniki, GreeceFirst Cardiology Department, AHEPA University Hospital, Aristotle University of Thessaloniki, Greece; Corresponding author. George Giannakoulas, MD, 1st Department of Cardiology AHEPA University Hospital, St. Kiriakidi 1, 54636, Thessaloniki, Greece. Tel.: +30 2313303589, Fax: +30 2313304673.Objectives: Chronic thromboembolic pulmonary hypertension (CTEPH) is a rare, distinct pulmonary vascular disease, and therefore, there is a lack of data regarding its clinical presentation, diagnosis, and management at a national basis. We aimed to describe the demographics and management of patients with CTEPH in Northern Greece. Methods: We conducted a retrospective, observational study by a joint collaboration between two pulmonary hypertension expert centers in Greece, and the study included patients diagnosed with CTEPH. The patient population was divided into two groups depending on their operability. Results: Overall, 27 consecutive patients were included (59% female, mean age 59.3±15.1 years). Dyspnea and fatigue were the most common presenting symptoms. History of pulmonary embolism was present in 82%. Of patients, 18 (67%) were assessed as operable, of whom 10 (55%) finally underwent pulmonary endarterectomy (PEA). There were no differences in symptoms, WHO functional class, 6-min walking test distance, and hemodynamics between the operable and nonoperable groups. At the end of follow-up, all non-operable and operable patients who did not receive surgical treatment were treated with at least one pulmonary hypertension-specific drug. Conclusion: This is the first report that presents data of patients diagnosed with CTEPH in Greece. The percentage of patients who underwent surgical treatment is lower but approaches the reported rates in large registries. Considering that PEA is a relatively safe and potentially curative surgical procedure, we emphasize the need for establishing a designated PEA center in Greece. Keywords: Chronic thromboembolic pulmonary hypertension, pulmonary endarterectomy, registry, riociguathttp://www.sciencedirect.com/science/article/pii/S1109966617300623 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Maria Anna Bazmpani Alexandra Arvanitaki Maria Toumpourleka Georgia Pitsiou Evangelia Panagiotidou Sophia Anastasia Mouratoglou Georgios Sianos Stavros Hadjimiltiades Antonios Pitsis Eckhard Mayer Ioannis Stanopoulos Haralambos Karvounis George Giannakoulas |
spellingShingle |
Maria Anna Bazmpani Alexandra Arvanitaki Maria Toumpourleka Georgia Pitsiou Evangelia Panagiotidou Sophia Anastasia Mouratoglou Georgios Sianos Stavros Hadjimiltiades Antonios Pitsis Eckhard Mayer Ioannis Stanopoulos Haralambos Karvounis George Giannakoulas Epidemiology and management of chronic thromboembolic pulmonary hypertension: experience from two expert centers Hellenic Journal of Cardiology |
author_facet |
Maria Anna Bazmpani Alexandra Arvanitaki Maria Toumpourleka Georgia Pitsiou Evangelia Panagiotidou Sophia Anastasia Mouratoglou Georgios Sianos Stavros Hadjimiltiades Antonios Pitsis Eckhard Mayer Ioannis Stanopoulos Haralambos Karvounis George Giannakoulas |
author_sort |
Maria Anna Bazmpani |
title |
Epidemiology and management of chronic thromboembolic pulmonary hypertension: experience from two expert centers |
title_short |
Epidemiology and management of chronic thromboembolic pulmonary hypertension: experience from two expert centers |
title_full |
Epidemiology and management of chronic thromboembolic pulmonary hypertension: experience from two expert centers |
title_fullStr |
Epidemiology and management of chronic thromboembolic pulmonary hypertension: experience from two expert centers |
title_full_unstemmed |
Epidemiology and management of chronic thromboembolic pulmonary hypertension: experience from two expert centers |
title_sort |
epidemiology and management of chronic thromboembolic pulmonary hypertension: experience from two expert centers |
publisher |
Elsevier |
series |
Hellenic Journal of Cardiology |
issn |
1109-9666 |
publishDate |
2018-01-01 |
description |
Objectives: Chronic thromboembolic pulmonary hypertension (CTEPH) is a rare, distinct pulmonary vascular disease, and therefore, there is a lack of data regarding its clinical presentation, diagnosis, and management at a national basis. We aimed to describe the demographics and management of patients with CTEPH in Northern Greece. Methods: We conducted a retrospective, observational study by a joint collaboration between two pulmonary hypertension expert centers in Greece, and the study included patients diagnosed with CTEPH. The patient population was divided into two groups depending on their operability. Results: Overall, 27 consecutive patients were included (59% female, mean age 59.3±15.1 years). Dyspnea and fatigue were the most common presenting symptoms. History of pulmonary embolism was present in 82%. Of patients, 18 (67%) were assessed as operable, of whom 10 (55%) finally underwent pulmonary endarterectomy (PEA). There were no differences in symptoms, WHO functional class, 6-min walking test distance, and hemodynamics between the operable and nonoperable groups. At the end of follow-up, all non-operable and operable patients who did not receive surgical treatment were treated with at least one pulmonary hypertension-specific drug. Conclusion: This is the first report that presents data of patients diagnosed with CTEPH in Greece. The percentage of patients who underwent surgical treatment is lower but approaches the reported rates in large registries. Considering that PEA is a relatively safe and potentially curative surgical procedure, we emphasize the need for establishing a designated PEA center in Greece. Keywords: Chronic thromboembolic pulmonary hypertension, pulmonary endarterectomy, registry, riociguat |
url |
http://www.sciencedirect.com/science/article/pii/S1109966617300623 |
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