Sustainable drug release from polycaprolactone coated chitin-lignin gel fibrous scaffolds
Abstract Non-healing wounds have placed an enormous stress on both patients and healthcare systems worldwide. Severe complications induced by these wounds can lead to limb amputation or even death and urgently require more effective treatments. Electrospun scaffolds have great potential for improvin...
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2020-11-01
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doaj-0390bead9023420b8ec15211d1d460822020-12-08T09:58:55ZengNature Publishing GroupScientific Reports2045-23222020-11-0110111210.1038/s41598-020-76971-wSustainable drug release from polycaprolactone coated chitin-lignin gel fibrous scaffoldsTuerdimaimaiti Abudula0Kalamegam Gauthaman1Azadeh Mostafavi2Ahmed Alshahrie3Numan Salah4Pierfrancesco Morganti5Angelo Chianese6Ali Tamayol7Adnan Memic8Center of Nanotechnology, King Abdulaziz UniversityCenter of Excellence in Genomic Medicine Research, King Abdulaziz UniversityDepartment of Mechanical and Materials Engineering, University of NebraskaCenter of Nanotechnology, King Abdulaziz UniversityCenter of Nanotechnology, King Abdulaziz UniversityAcademy of History of Healthcare ArtLABOR SrlDepartment of Mechanical and Materials Engineering, University of NebraskaCenter of Nanotechnology, King Abdulaziz UniversityAbstract Non-healing wounds have placed an enormous stress on both patients and healthcare systems worldwide. Severe complications induced by these wounds can lead to limb amputation or even death and urgently require more effective treatments. Electrospun scaffolds have great potential for improving wound healing treatments by providing controlled drug delivery. Previously, we developed fibrous scaffolds from complex carbohydrate polymers [i.e. chitin-lignin (CL) gels]. However, their application was limited by solubility and undesirable burst drug release. Here, a coaxial electrospinning is applied to encapsulate the CL gels with polycaprolactone (PCL). Presence of a PCL shell layer thus provides longer shelf-life for the CL gels in a wet environment and sustainable drug release. Antibiotics loaded into core–shell fibrous platform effectively inhibit both gram-positive and -negative bacteria without inducting observable cytotoxicity. Therefore, PCL coated CL fibrous gel platforms appear to be good candidates for controlled drug release based wound dressing applications.https://doi.org/10.1038/s41598-020-76971-w |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Tuerdimaimaiti Abudula Kalamegam Gauthaman Azadeh Mostafavi Ahmed Alshahrie Numan Salah Pierfrancesco Morganti Angelo Chianese Ali Tamayol Adnan Memic |
spellingShingle |
Tuerdimaimaiti Abudula Kalamegam Gauthaman Azadeh Mostafavi Ahmed Alshahrie Numan Salah Pierfrancesco Morganti Angelo Chianese Ali Tamayol Adnan Memic Sustainable drug release from polycaprolactone coated chitin-lignin gel fibrous scaffolds Scientific Reports |
author_facet |
Tuerdimaimaiti Abudula Kalamegam Gauthaman Azadeh Mostafavi Ahmed Alshahrie Numan Salah Pierfrancesco Morganti Angelo Chianese Ali Tamayol Adnan Memic |
author_sort |
Tuerdimaimaiti Abudula |
title |
Sustainable drug release from polycaprolactone coated chitin-lignin gel fibrous scaffolds |
title_short |
Sustainable drug release from polycaprolactone coated chitin-lignin gel fibrous scaffolds |
title_full |
Sustainable drug release from polycaprolactone coated chitin-lignin gel fibrous scaffolds |
title_fullStr |
Sustainable drug release from polycaprolactone coated chitin-lignin gel fibrous scaffolds |
title_full_unstemmed |
Sustainable drug release from polycaprolactone coated chitin-lignin gel fibrous scaffolds |
title_sort |
sustainable drug release from polycaprolactone coated chitin-lignin gel fibrous scaffolds |
publisher |
Nature Publishing Group |
series |
Scientific Reports |
issn |
2045-2322 |
publishDate |
2020-11-01 |
description |
Abstract Non-healing wounds have placed an enormous stress on both patients and healthcare systems worldwide. Severe complications induced by these wounds can lead to limb amputation or even death and urgently require more effective treatments. Electrospun scaffolds have great potential for improving wound healing treatments by providing controlled drug delivery. Previously, we developed fibrous scaffolds from complex carbohydrate polymers [i.e. chitin-lignin (CL) gels]. However, their application was limited by solubility and undesirable burst drug release. Here, a coaxial electrospinning is applied to encapsulate the CL gels with polycaprolactone (PCL). Presence of a PCL shell layer thus provides longer shelf-life for the CL gels in a wet environment and sustainable drug release. Antibiotics loaded into core–shell fibrous platform effectively inhibit both gram-positive and -negative bacteria without inducting observable cytotoxicity. Therefore, PCL coated CL fibrous gel platforms appear to be good candidates for controlled drug release based wound dressing applications. |
url |
https://doi.org/10.1038/s41598-020-76971-w |
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