Dissecting the Molecular Mechanisms of Neurodegenerative Diseases through Network Biology
Neurodegenerative diseases are rarely caused by a mutation in a single gene but rather influenced by a combination of genetic, epigenetic and environmental factors. Emerging high-throughput technologies such as RNA sequencing have been instrumental in deciphering the molecular landscape of neurodege...
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doaj-03a10520133f4698a3a40e1ed9109f052020-11-24T23:56:06ZengFrontiers Media S.A.Frontiers in Aging Neuroscience1663-43652017-05-01910.3389/fnagi.2017.00166237581Dissecting the Molecular Mechanisms of Neurodegenerative Diseases through Network BiologyJose A. Santiago0Virginie Bottero1Judith A. Potashkin2epartment of Cellular and Molecular Pharmacology, The Chicago Medical School, Rosalind Franklin University of Medicine and ScienceNorth Chicago, IL, United Statesepartment of Cellular and Molecular Pharmacology, The Chicago Medical School, Rosalind Franklin University of Medicine and ScienceNorth Chicago, IL, United Statesepartment of Cellular and Molecular Pharmacology, The Chicago Medical School, Rosalind Franklin University of Medicine and ScienceNorth Chicago, IL, United StatesNeurodegenerative diseases are rarely caused by a mutation in a single gene but rather influenced by a combination of genetic, epigenetic and environmental factors. Emerging high-throughput technologies such as RNA sequencing have been instrumental in deciphering the molecular landscape of neurodegenerative diseases, however, the interpretation of such large amounts of data remains a challenge. Network biology has become a powerful platform to integrate multiple omics data to comprehensively explore the molecular networks in the context of health and disease. In this review article, we highlight recent advances in network biology approaches with an emphasis in brain-networks that have provided insights into the molecular mechanisms leading to the most prevalent neurodegenerative diseases including Alzheimer’s (AD), Parkinson’s (PD) and Huntington’s diseases (HD). We discuss how integrative approaches using multi-omics data from different tissues have been valuable for identifying biomarkers and therapeutic targets. In addition, we discuss the challenges the field of network medicine faces toward the translation of network-based findings into clinically actionable tools for personalized medicine applications.http://journal.frontiersin.org/article/10.3389/fnagi.2017.00166/fullAlzheimer’s diseaseParkinson’s diseaseHuntington’s diseasenetwork biologymolecular mechanisms |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Jose A. Santiago Virginie Bottero Judith A. Potashkin |
spellingShingle |
Jose A. Santiago Virginie Bottero Judith A. Potashkin Dissecting the Molecular Mechanisms of Neurodegenerative Diseases through Network Biology Frontiers in Aging Neuroscience Alzheimer’s disease Parkinson’s disease Huntington’s disease network biology molecular mechanisms |
author_facet |
Jose A. Santiago Virginie Bottero Judith A. Potashkin |
author_sort |
Jose A. Santiago |
title |
Dissecting the Molecular Mechanisms of Neurodegenerative Diseases through Network Biology |
title_short |
Dissecting the Molecular Mechanisms of Neurodegenerative Diseases through Network Biology |
title_full |
Dissecting the Molecular Mechanisms of Neurodegenerative Diseases through Network Biology |
title_fullStr |
Dissecting the Molecular Mechanisms of Neurodegenerative Diseases through Network Biology |
title_full_unstemmed |
Dissecting the Molecular Mechanisms of Neurodegenerative Diseases through Network Biology |
title_sort |
dissecting the molecular mechanisms of neurodegenerative diseases through network biology |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Aging Neuroscience |
issn |
1663-4365 |
publishDate |
2017-05-01 |
description |
Neurodegenerative diseases are rarely caused by a mutation in a single gene but rather influenced by a combination of genetic, epigenetic and environmental factors. Emerging high-throughput technologies such as RNA sequencing have been instrumental in deciphering the molecular landscape of neurodegenerative diseases, however, the interpretation of such large amounts of data remains a challenge. Network biology has become a powerful platform to integrate multiple omics data to comprehensively explore the molecular networks in the context of health and disease. In this review article, we highlight recent advances in network biology approaches with an emphasis in brain-networks that have provided insights into the molecular mechanisms leading to the most prevalent neurodegenerative diseases including Alzheimer’s (AD), Parkinson’s (PD) and Huntington’s diseases (HD). We discuss how integrative approaches using multi-omics data from different tissues have been valuable for identifying biomarkers and therapeutic targets. In addition, we discuss the challenges the field of network medicine faces toward the translation of network-based findings into clinically actionable tools for personalized medicine applications. |
topic |
Alzheimer’s disease Parkinson’s disease Huntington’s disease network biology molecular mechanisms |
url |
http://journal.frontiersin.org/article/10.3389/fnagi.2017.00166/full |
work_keys_str_mv |
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