African Non-Human Primates Host Diverse Enteroviruses.
Enteroviruses (EVs) belong to the family Picornaviridae and are responsible for mild to severe diseases in mammals including humans and non-human primates (NHP). Simian EVs were first discovered in the 1950s in the Old World Monkeys and recently in wild chimpanzee, gorilla and mandrill in Cameroon....
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doaj-03a6031e578847cdaa266aa37104fbc82020-11-24T20:45:28ZengPublic Library of Science (PLoS)PLoS ONE1932-62032017-01-01121e016906710.1371/journal.pone.0169067African Non-Human Primates Host Diverse Enteroviruses.Illich Manfred MomboAlexander N LukashevTobias BleickerSebastian BrüninkNicolas BerthetGael D MagangaPatrick DurandCéline ArnathauLarson BoundengaBarthélémy NgoubangoyeVanina BouéFlorian LiégeoisBenjamin OllomoFranck PrugnolleJan Felix DrexlerChristian DrostenFrançois RenaudVirginie RougeronEric LeroyEnteroviruses (EVs) belong to the family Picornaviridae and are responsible for mild to severe diseases in mammals including humans and non-human primates (NHP). Simian EVs were first discovered in the 1950s in the Old World Monkeys and recently in wild chimpanzee, gorilla and mandrill in Cameroon. In the present study, we screened by PCR EVs in 600 fecal samples of wild apes and monkeys that were collected at four sites in Gabon. A total of 32 samples were positive for EVs (25 from mandrills, 7 from chimpanzees, none from gorillas). The phylogenetic analysis of VP1 and VP2 genes showed that EVs identified in chimpanzees were members of two human EV species, EV-A and EV-B, and those identified in mandrills were members of the human species EV-B and the simian species EV-J. The identification of two novel enterovirus types, EV-B112 in a chimpanzee and EV-B113 in a mandrill, suggests these NHPs could be potential sources of new EV types. The identification of EV-B107 and EV90 that were previously found in humans indicates cross-species transfers. Also the identification of chimpanzee-derived EV110 in a mandrill demonstrated a wide host range of this EV. Further research of EVs in NHPs would help understanding emergence of new types or variants, and evaluating the real risk of cross-species transmission for humans as well for NHPs populations.http://europepmc.org/articles/PMC5233426?pdf=render |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Illich Manfred Mombo Alexander N Lukashev Tobias Bleicker Sebastian Brünink Nicolas Berthet Gael D Maganga Patrick Durand Céline Arnathau Larson Boundenga Barthélémy Ngoubangoye Vanina Boué Florian Liégeois Benjamin Ollomo Franck Prugnolle Jan Felix Drexler Christian Drosten François Renaud Virginie Rougeron Eric Leroy |
spellingShingle |
Illich Manfred Mombo Alexander N Lukashev Tobias Bleicker Sebastian Brünink Nicolas Berthet Gael D Maganga Patrick Durand Céline Arnathau Larson Boundenga Barthélémy Ngoubangoye Vanina Boué Florian Liégeois Benjamin Ollomo Franck Prugnolle Jan Felix Drexler Christian Drosten François Renaud Virginie Rougeron Eric Leroy African Non-Human Primates Host Diverse Enteroviruses. PLoS ONE |
author_facet |
Illich Manfred Mombo Alexander N Lukashev Tobias Bleicker Sebastian Brünink Nicolas Berthet Gael D Maganga Patrick Durand Céline Arnathau Larson Boundenga Barthélémy Ngoubangoye Vanina Boué Florian Liégeois Benjamin Ollomo Franck Prugnolle Jan Felix Drexler Christian Drosten François Renaud Virginie Rougeron Eric Leroy |
author_sort |
Illich Manfred Mombo |
title |
African Non-Human Primates Host Diverse Enteroviruses. |
title_short |
African Non-Human Primates Host Diverse Enteroviruses. |
title_full |
African Non-Human Primates Host Diverse Enteroviruses. |
title_fullStr |
African Non-Human Primates Host Diverse Enteroviruses. |
title_full_unstemmed |
African Non-Human Primates Host Diverse Enteroviruses. |
title_sort |
african non-human primates host diverse enteroviruses. |
publisher |
Public Library of Science (PLoS) |
series |
PLoS ONE |
issn |
1932-6203 |
publishDate |
2017-01-01 |
description |
Enteroviruses (EVs) belong to the family Picornaviridae and are responsible for mild to severe diseases in mammals including humans and non-human primates (NHP). Simian EVs were first discovered in the 1950s in the Old World Monkeys and recently in wild chimpanzee, gorilla and mandrill in Cameroon. In the present study, we screened by PCR EVs in 600 fecal samples of wild apes and monkeys that were collected at four sites in Gabon. A total of 32 samples were positive for EVs (25 from mandrills, 7 from chimpanzees, none from gorillas). The phylogenetic analysis of VP1 and VP2 genes showed that EVs identified in chimpanzees were members of two human EV species, EV-A and EV-B, and those identified in mandrills were members of the human species EV-B and the simian species EV-J. The identification of two novel enterovirus types, EV-B112 in a chimpanzee and EV-B113 in a mandrill, suggests these NHPs could be potential sources of new EV types. The identification of EV-B107 and EV90 that were previously found in humans indicates cross-species transfers. Also the identification of chimpanzee-derived EV110 in a mandrill demonstrated a wide host range of this EV. Further research of EVs in NHPs would help understanding emergence of new types or variants, and evaluating the real risk of cross-species transmission for humans as well for NHPs populations. |
url |
http://europepmc.org/articles/PMC5233426?pdf=render |
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