Synergistic Cytotoxicity of Renieramycin M and Doxorubicin in MCF-7 Breast Cancer Cells

Synergistic Cytotoxicity of Renieramycin M and Doxorubicin in MCF-7 Breast Cancer Cells

Renieramycin M (RM) is a KCN-stabilized tetrahydroisoquinoline purified from the blue sponge <i>Xestospongia</i> sp., with nanomolar IC<sub>50</sub>s against several cancer cell lines. Our goal is to evaluate its combination effects with doxorubicin (DOX) in estrogen receptor...

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Bibliographic Details
Main Authors:	Jortan O. Tun, Lilibeth A. Salvador-Reyes, Michael C. Velarde, Naoki Saito, Khanit Suwanborirux, Gisela P. Concepcion
Format:	Article
Language:	English
Published:	MDPI AG 2019-09-01
Series:	Marine Drugs
Subjects:	renieramycin M doxorubicin synergistic combination chemotherapy real-time profiling cell cycle gene expression profiling apoptosis breast cancer blue sponge DNA damage response
Online Access:	https://www.mdpi.com/1660-3397/17/9/536

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