Usefulness of neutrophil-lymphocyte ratio in young children with febrile urinary tract infection
PurposeAcute pyelonephritis (APN) is a serious bacterial infection that can cause renal scarring in children. Early identification of APN is critical to improve treatment outcomes. The neutrophil-lymphocyte ratio (NLR) is a prognostic marker of many diseases, but it has not yet been established in u...
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Korean Pediatric Society
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doaj-03b3ee2be0ce48ba839253f01b3fce202020-11-24T22:37:37ZengKorean Pediatric SocietyKorean Journal of Pediatrics1738-10612092-72582016-03-0159313914410.3345/kjp.2016.59.3.13920125550529Usefulness of neutrophil-lymphocyte ratio in young children with febrile urinary tract infectionSong Yi Han0I Re Lee1Se Jin Park2Ji Hong Kim3Jae Il Shin4Department of Pediatrics, Yonsei University College of Medicine, Seoul, Korea.Department of Pediatrics, Yonsei University College of Medicine, Seoul, Korea.Department of Pediatrics, Daewoo General Hospital, Ajou University School of Medicine, Geoje, Korea.Department of Pediatrics, Yonsei University College of Medicine, Seoul, Korea.Department of Pediatrics, Yonsei University College of Medicine, Seoul, Korea.PurposeAcute pyelonephritis (APN) is a serious bacterial infection that can cause renal scarring in children. Early identification of APN is critical to improve treatment outcomes. The neutrophil-lymphocyte ratio (NLR) is a prognostic marker of many diseases, but it has not yet been established in urinary tract infection (UTI). The aim of this study was to determine whether NLR is a useful marker to predict APN or vesicoureteral reflux (VUR).MethodsWe retrospectively evaluated 298 pediatric patients (age≤36 months) with febrile UTI from January 2010 to December 2014. Conventional infection markers (white blood cell [WBC] count, erythrocyte sedimentation rate [ESR], C-reactive protein [CRP]), and NLR were measured.ResultsWBC, CRP, ESR, and NLR were higher in APN than in lower UTI (P<0.001). Multiple logistic regression analyses showed that NLR was a predictive factor for positive dimercaptosuccinic acid (DMSA) defects (P<0.001). The area under the receiver operating characteristic (ROC) curve was high for NLR (P<0.001) as well as CRP (P<0.001) for prediction of DMSA defects. NLR showed the highest area under the ROC curve for diagnosis of VUR (P<0.001).ConclusionNLR can be used as a diagnostic marker of APN with DMSA defect, showing better results than those of conventional markers for VUR prediction.http://kjp.or.kr/upload/pdf/kjped-59-139.pdfUrinary tract infectionsPyelonephritisVesico-ureteral refluxChildNeutrophil-lymphocyte ratio |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Song Yi Han I Re Lee Se Jin Park Ji Hong Kim Jae Il Shin |
spellingShingle |
Song Yi Han I Re Lee Se Jin Park Ji Hong Kim Jae Il Shin Usefulness of neutrophil-lymphocyte ratio in young children with febrile urinary tract infection Korean Journal of Pediatrics Urinary tract infections Pyelonephritis Vesico-ureteral reflux Child Neutrophil-lymphocyte ratio |
author_facet |
Song Yi Han I Re Lee Se Jin Park Ji Hong Kim Jae Il Shin |
author_sort |
Song Yi Han |
title |
Usefulness of neutrophil-lymphocyte ratio in young children with febrile urinary tract infection |
title_short |
Usefulness of neutrophil-lymphocyte ratio in young children with febrile urinary tract infection |
title_full |
Usefulness of neutrophil-lymphocyte ratio in young children with febrile urinary tract infection |
title_fullStr |
Usefulness of neutrophil-lymphocyte ratio in young children with febrile urinary tract infection |
title_full_unstemmed |
Usefulness of neutrophil-lymphocyte ratio in young children with febrile urinary tract infection |
title_sort |
usefulness of neutrophil-lymphocyte ratio in young children with febrile urinary tract infection |
publisher |
Korean Pediatric Society |
series |
Korean Journal of Pediatrics |
issn |
1738-1061 2092-7258 |
publishDate |
2016-03-01 |
description |
PurposeAcute pyelonephritis (APN) is a serious bacterial infection that can cause renal scarring in children. Early identification of APN is critical to improve treatment outcomes. The neutrophil-lymphocyte ratio (NLR) is a prognostic marker of many diseases, but it has not yet been established in urinary tract infection (UTI). The aim of this study was to determine whether NLR is a useful marker to predict APN or vesicoureteral reflux (VUR).MethodsWe retrospectively evaluated 298 pediatric patients (age≤36 months) with febrile UTI from January 2010 to December 2014. Conventional infection markers (white blood cell [WBC] count, erythrocyte sedimentation rate [ESR], C-reactive protein [CRP]), and NLR were measured.ResultsWBC, CRP, ESR, and NLR were higher in APN than in lower UTI (P<0.001). Multiple logistic regression analyses showed that NLR was a predictive factor for positive dimercaptosuccinic acid (DMSA) defects (P<0.001). The area under the receiver operating characteristic (ROC) curve was high for NLR (P<0.001) as well as CRP (P<0.001) for prediction of DMSA defects. NLR showed the highest area under the ROC curve for diagnosis of VUR (P<0.001).ConclusionNLR can be used as a diagnostic marker of APN with DMSA defect, showing better results than those of conventional markers for VUR prediction. |
topic |
Urinary tract infections Pyelonephritis Vesico-ureteral reflux Child Neutrophil-lymphocyte ratio |
url |
http://kjp.or.kr/upload/pdf/kjped-59-139.pdf |
work_keys_str_mv |
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